ESMO Consensus Conference on Malignant Lymphoma: Management of ‘ultra-high-risk’ Patients

Published in 2018 – Ann Oncol (2018); 29: 1687–1700
Authors: M. Hutchings, M. Ladetto, C. Buske, P. de Nully Brown, A.J.M. Ferreri, M. Pfreundschuh, N. Schmitz, A. Sureda Balari, G. van Imhoff, J. Walewski & the ESMO Lymphoma Consensus Conference Panel Members

In order to complement the already available European Society for Medical Oncology (ESMO) Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with malignant lymphomas, ESMO organised a consensus conference on mature B-cell lymphomas and chronic lymphocytic leukaemia to develop recommendations on critical subjects difficult to consider in detail in the ESMO Clinical Practice Guidelines. The following areas were identified: (i) the elderly patient, (ii) prognostic factors suitable for clinical use and (iii) the 'ultra-high-risk' group.

This manuscript presents recommendations on the clinical management of ‘ultra-high-risk’ patients with malignant lymphoma and was compiled by a multidisciplinary panel of 25 experts. It provides clear guidance on the management of the following high-risk situations: DLBCL with CNS relapse, primary refractory HL and PBL. Recommendations provided are accompanied by relevant supporting evidence. 

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