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ESMO-Magnitude of Clinical Benefit Scale Working Group

The ESMO-MCBS is a dynamic tool and one of the main tasks of the ESMO-MCBS Working Group is to maintain the scale and to revise when necessary

The ESMO-MCBS Working Group works in the field of development, research, and education regarding the ESMO-MCBS, a reference tool used by many diverse stakeholders in addressing the issue of value in cancer medicines and treatments.

Activities and Responsibilities

  • Maintain and update the scale
  • Guarantee continual quality assessment that addresses peer and stakeholder feedback and appeals
  • Oversee adherence to highest standards of validity and reasonableness in all ESMO-MCBS processes
  • Evaluate and score cancer medicines and treatments approved by regulatory bodies such as the European Medicines Agency
  • Provide ESMO-MCBS scores for inclusion in the ESMO Clinical Practice Guidelines
  • Update ESMO-MCBS scores when new peer-reviewed evidence becomes available
  • Promote clear and unbiased communication about the benefits of cancer treatments
  • Knowledge sharing of the tool within the global oncology community


  • Sjoukje Oosting, Netherlands

Working Group Members

  • Dirk Arnold, Germany
  • Nathan I. Cherny, Israel
  • Giuseppe Curigliano, Italy
  • Elisabeth G.E. de Vries, Netherlands
  • Bishal Gyawali, Canada
  • Barbara Kiesewetter, Austria
  • Felipe Roitberg, Brazil
  • Lydia Scarfò, Italy
  • Elizabeth Smyth, United Kingdom
  • Dario Trapani, Italy

Extended Working Group Members

  • Teresa Amaral, Germany
  • Jorge Barriuso, United Kingdom
  • Eva Blondeaux, Italy
  • Raffaella Casolino, Switzerland
  • Roberto Ferrara, Italy
  • Carlos Gomez-Roca, France
  • Thomas Hwang, United States of America
  • Emre Kocakavuk, Germany
  • Alexios Matikas, Sweden
  • Aju Mathew, India
  • Tomer Meirson, Israel
  • Madeleine Pe, Belgium
  • Martine Piccart, Belgium
  • José Luis Sandoval, Switzerland
  • Eva Segelov, Switzerland
  • Noelia Tarazona Llavero, Spain
  • Johan Vansteenkiste, Belgium
  • Ruth Wester, Netherlands
  • George Zarkavelis, Greece
  • Hongcheng Zhu, China

Biostatistical support provided by Frontier Science Foundation - Hellas

Last update: April 2024

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