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Pan-Asian Guidelines Adaptation (PAGA)

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The Pan-Asian Guidelines Adaptation (PAGA) project aims to adapt the ESMO Clinical Practice Guidelines by integrating Asian ethnic, scientific, socioeconomic, and local practice characteristics.

The project provides a framework for the structured interaction of key opinion leaders in oncology from Asia and Europe.

Tailoring the ESMO Clinical Practice Guidelines to the local context results in a resource-efficient, valuable tool that can be used by health professionals and patients to harmonise optimal, evidence-based practice across Asia, focus on ethnic differences and potentially approach regulatory authorities.

Started in 2016 as a collaboration between ESMO and the Japanese Society of Medical Oncology (JSMO), the PAGA project has grown and flourished with the active collaboration of the oncology societies of China (CSCO), India (ISMPO), Indonesia (ISHMO), Japan (JSMO), South Korea (KSMO), Malaysia (MOS), Philippines (PSMO), Singapore (SSO), Taiwan (TOS), and Thailand (TSCO). Every year, Asian experts from these collaborating societies engage in productive scientific interactions with their European counterparts to build consensus towards Pan-Asian adaptation of three to four ESMO Clinical Practice Guidelines, which are then published in ESMO Open and presented at the ESMO Asia Congress.

Collaborating societies

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Alvin Tan

Alvin Tan

“Participating in the development of the PAGA guidelines has given me insight into the collaborative effort, time and goodwill between clinicians across multiple countries to gather and discuss the practical aspects of clinical guidelines and how we might apply them to our respective countries.”

Alvin Tan, ESMO Leaders Generation Programme Asia Alumni, New Zealand

Su Pin Choo

Su Pin Choo

“Some aspects of oncology treatment described in the ESMO Clinical Practice Guidelines are not applicable to the Asian context. That's where the PAGA guidelines can fill the gap and be internationally recognised guidelines suited to Asian oncology practices. 

Participating in the development of the PAGA guidelines allowed me to work with thought leaders from various Asian countries and has given me a better understanding of oncology practices in their countries.”

Su Pin Choo, SSO Immediate Past President, Singapore

Takayuki Yoshino

Takayuki Yoshino

Taking into account the ethnic differences of the Asian cancer patient population in terms of drug reaction and biomarkers, the Pan-Asian ESMO Guidelines provide high-quality and evidence-based recommendations for sustainable cancer care. I am confident that the PAGA project will be useful to promote availability of new drugs in Asia and the proposal to the Regulatory Agency in each Asian country, supporting in particular those countries where resources are lacking to advocate for improving cancer care locally.

Takayuki Yoshino, International Coordinator of the Pan-Asian Guidelines adaptation (PAGA) project

ISMPO 2022

ISMPO 2022

PAGA Endometrial cancer meeting (Virtual, July 2022) hosted by ISMPO

SSO 2021

SSO 2021

SSO 2021 PAGA Prostate cancer meeting (Virtual, November 2021) hosted by SSO

SSO 2021

SSO 2021

PAGA Renal cancer meeting (Virtual 2021, May 2021) hosted by SSO 

KSMO 2021

KSMO 2021

PAGA Head & neck cancer meeting (Virtual, July 2021) hosted by KSMO 

JSMO 2017

JSMO 2017

PAGA Metastatic colorectal cancer meeting (Japan, July 2017) hosted by JSMO

Available PAGA Guidelines

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