ESMO Symposium on Signalling Pathways in Cancer 2019 in partnership with the EACR focuses on gene fusions from gene architecture evolution to cell addiction and therapeutic opportunities. ESMO and EACR Co-Chairs, Drs Andrea Sartore-Bianchi and Joan Seoane discuss the relevance of gene fusions in oncology, what to expect from the programme, concept of the sessions, who may benefit from attendance, and why it is important that societies like ESMO and EACR collaborate in such a Symposium. They welcome all delegates from 26 to 27 April 2019 in Barcelona, Spain.