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ESMO-MCBS Scorecards

ESMO MCBS  1000x150

The ESMO-MCBS Scorecards provides a centralised location of cancer medicines that have been scored and published by ESMO.

It includes all cancer medicines approved by the European Medicines Agency (from January 2016) and the US Food and Drug Administration (from January 2020).

ESMO-MCBS Scores
Number of studies
Non-curative setting
5 17
4 95
3 125
2 34
1 19
Curative setting
A 38
C 2
ESMO-MCBS Scores by tumour type
Non-curative setting
Breast Cancer 28
Central Nervous System Malignancies 0
Endocrine Tumours 19
Gastrointestinal Cancers 53
Genitourinary Cancers 51
Gynaecological Malignancies 30
Head and neck cancer 6
Refractory NTRK fusion–positive cancers 2
Sarcoma 10
Skin Cancers 24
TMB-H solid tumours 1
Thoracic Malignancies 65
dMMR/MSI-H solid tumours 1
Curative setting
Breast Cancer 8
Central Nervous System Malignancies 1
Endocrine Tumours 0
Gastrointestinal Cancers 15
Genitourinary Cancers 4
Gynaecological Malignancies 0
Head and neck cancer 0
Refractory NTRK fusion–positive cancers 0
Sarcoma 2
Skin Cancers 8
TMB-H solid tumours 0
Thoracic Malignancies 2
dMMR/MSI-H solid tumours 0

The ESMO-MCBS Scorecards

The ESMO-MCBS Scorecards allows you to filter either by Agent, Tumour or Score giving priority to different criteria such as Agent and Tumour Type and Tumour sub-type and Tumour sub-group in the Curative or Non-curative setting. This content will be updated regularly and communicated to ESMO Members.

Evaluation form 1 For new approaches to adjuvant therapy or new potentially curative therapies
Evaluation form 2a For therapies that are not likely to be curative with primary endpoint of OS with separate sheets for:
Evaluation form 2b For therapies that are not likely to be curative with primary endpoint PFS with separate sheets for:
Evaluation form 2c  For therapies that are not likely to be curative with primary endpoint other than OS or PFS or equivalent (non-inferiority) studies
Evaluation form 3  For single-arm studies in “orphan diseases” and for diseases with “high unmet need” when primary outcome is PFS or ORR.

My watchlist

    Tested Agent(s) Combined Agent(s) Control Arm Treatment Setting Tumour Type Tumour Sub-type Tumour Sub-group Trial Name Ref. Score Scorecard Scorecard
    Nivo/Ipi (nivolumab and ipilimumab) - Sunitinib 1st line for intermediate/poor risk advanced renal cell carcinoma Genitourinary Cancers Renal cell cancer - CheckMate 214
    4

    PRELIMINARY SCORE

    • OS
      5

    ADJUSTMENTS

    FINAL SCORE

    • F1
      2
    Osimertinib - Gefitinib or erlotinib Previously untreated EGFR mutated (exon 19 deletion or L858R) Thoracic Malignancies Non-small-cell Lung Cancer EGFR+ (exon 19 deletion or L858R) FLAURA
    4

    PRELIMINARY SCORE

    • OS
      6

    ADJUSTMENTS

    FINAL SCORE

    • F1
      2
    Alectinib - Crizotinib Untreated ALK-positive Thoracic Malignancies Non-small-cell Lung Cancer ALK+ J-ALEX
    4

    PRELIMINARY SCORE

    • OS
      6

    ADJUSTMENTS

    FINAL SCORE

    • F1
      2
    Alectinib - Chemotherapy (pemetrexed or docetaxel) ALK-positive advanced NSCLC previously treated with crizotinib Thoracic Malignancies Non-small-cell Lung Cancer ALK+ ALUR
    4

    PRELIMINARY SCORE

    • OS
      6

    ADJUSTMENTS

    FINAL SCORE

    • F1
      2
    Ceritinib - Chemotherapy (pemetrexed or docetaxel) Previously treated with chemotherapy and crizotinib ALK-positive stage IIIB or IV Thoracic Malignancies Non-small-cell Lung Cancer ALK+ ASCEND-5
    4

    PRELIMINARY SCORE

    • OS
      6

    ADJUSTMENTS

    FINAL SCORE

    • F1
      2
    Ceritinib - Chemotherapy 1st line ALK positive Thoracic Malignancies Non-small-cell Lung Cancer ALK+ ASCEND-4
    4

    PRELIMINARY SCORE

    • OS
      6

    ADJUSTMENTS

    FINAL SCORE

    • F1
      2
    Pembrolizumab Chemotherapy (Pemetrexed) Chemotherapy Previously untreated without EGFR or ALK mutations Thoracic Malignancies Non-small-cell Lung Cancer - KEYNOTE-189
    4

    PRELIMINARY SCORE

    • OS
      5

    ADJUSTMENTS

    FINAL SCORE

    • F1
      2
    Olaparib - Placebo Maintenance therapy in newly diagnosed women with advanced high-grade cancer of the ovaries, fallopian tubes and peritoneum with BRCA mutations who have been treated with platinum-based ChT and in whom this treatment has reduced or cleared the cancer Gynaecological Malignancies Ovarian, fallopian tubes and peritoneum cancer BRCA mutation SOLO-1
    4

    PRELIMINARY SCORE

    • OS
      6

    ADJUSTMENTS

    FINAL SCORE

    • F1
      2
    Olaparib - Placebo Maintenance therapy in relapsed high-grade cancer of the ovaries, fallopian tubes and peritoneum with BRCA mutations after previous treatment and in whom platinum-based chemotherapy has reduced or cleared the cancer Gynaecological Malignancies Ovarian, fallopian tubes and peritoneum cancer BRCA mutation SOLO-2
    4

    PRELIMINARY SCORE

    • OS
      6

    ADJUSTMENTS

    FINAL SCORE

    • F1
      2
    Pembrolizumab Axitinib Sunitinib Previously untreated advanced renal cell carcinoma  Genitourinary Cancers Renal cell cancer - KEYNOTE-426
    4

    PRELIMINARY SCORE

    • OS
      6

    ADJUSTMENTS

    FINAL SCORE

    • F1
      2

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