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In tumours with high mutational burden treated with ICI, improved overall survival associated mainly with mutations in the POLE gene and with defective DNA mismatch repair
Evidence for efficacy is based on the results of KEYNOTE-590 study
New indication concerns first-line treatment of patients with metastatic NSCLC whose tumours have high PD-L1 expression
Results from the ASTEROID study with durvalumab after stereotactic body radiotherapy in patients with early stage non-small cell lung cancer
Results from early halted PIPSeN study in chemonaïve patients with non-small cell lung cancer without EGFR or ALK/ROS alterations
Changes were made in the delivery of radical radiotherapy across the UK in response to COVID-19 adapted guidelines
Data with approximately 3 years of follow-up from the KEYNOTE-407 study show improved survival with pembrolizumab added to chemotherapy
Molecular characterisation of tumours with alterations in the PIK3 pathway
More patients diagnosed with stage IV non-small cell lung cancer presented with brain metastases compared to historic rates
Findings from a large analysis of the GENIE Cohort v8.1
Agents with CNS activity may have improved outcomes for patients with non-small cell lung cancer and brain metastases at diagnosis
A deep-learning algorithm can help to discriminate radiation pneumonitis from COVID-19 pneumonia
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