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EANO-ESMO Clinical Practice Guideline – Leptomeningeal Metastasis

Leptomeningeal metastasis from solid tumours: EANO–ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up


ESMO Open. 2023;8(5):101624.
Le Rhun E, Weller M, van den Bent M, et al., on behalf of the EANO Guidelines Committee and ESMO Guidelines Committee

  • This Clinical Practice Guideline provides recommendations for managing leptomeningeal metastases from solid tumours.
  • The guideline covers clinical, imaging and cytological diagnosis, staging and risk assessment, treatment and follow-up.
  • A treatment and management algorithm is provided.
  • The author panel encompasses a multidisciplinary group of experts from different institutions and countries in Europe.
  • Recommendations are based on available scientific data and the authors’ collective expert opinion.


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