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Clinical Practice Guideline – Cancers of Unknown Primary Site

Cancer of unknown primary: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up

Ann Oncol. 2023;34(3):228-246.
Krämer A, Bochtler T, Pauli C, et al, on behalf of the ESMO Guidelines Committee.

  • This ESMO Clinical Practice Guideline provides key recommendations for managing cancer of unknown primary (CUP).
  • The guideline covers CUP diagnosis, risk assessment, classification, treatment and follow-up.
  • Differential diagnostic algorithms for discrimination between CUP and other cancers are provided.
  • The author group includes multidisciplinary experts from different institutions in Europe, Australia and the United States.
  • Recommendations are based on available scientific data and the authors’ collective expert opinion.
  • In clinical practice, all recommendations provided need to be discussed with patients in a shared decision-making approach.

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