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4
ESMO-MCBS v1.1
Scorecard version: 1

Indication details

Tumour Type
Thoracic Malignancies
Tumour Sub-type
Non-small-cell Lung Cancer
Tumour stage
Metastatic
Control Arm
Placebo
Treatment Setting
Stage III or IV disease maintenance after responding to 4 cycles platinum doublet

Primary Outcome(s)

Primary Outcome(s)
PFS stratified for histology (non-squamous)
Form(s)
Form 2a

Outcome Data

PFS Control
2.6 months
PFS Gain
1.7 months
PFS HR
0.50 (0.42-0.61)
OS Control
10.3 months
OS Gain
5.2 months
OS HR
0.70 (0.56-0.88)

Final Score (after adjustments)

Preliminary non-curative score
4
Final non-curative Score
4

DFS, disease-free survival; DoR, duration of response; EFS, event-free survival; HR, hazard ratio; ORR, overall response rate; OS, overall survival; pCR, pathologic complete response/remission; PFS, progression-free survival; QoL, quality of life; RFS, relapse-free survival; RR, response rate

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