3
Indication details
- Combined Agent(s)
- Paclitaxel + carboplatin
- Control Arm
- Paclitaxel + carboplatin
- Therapeutic Indication
- In combination with carboplatin and paclitaxel for the front-line treatment of adult patients with advanced (FIGO stage IIIB, IIIC, IV) epithelial ovarian, fallopian tube, or primary peritoneal cancer
- Tumour Type
-
Gynaecological Malignancies
- Tumour Sub-type
- Ovarian Cancer
- Tumour Stage
- Advanced
- Tumour Sub-Group
- High risk
- Trial Name
- ICON7
- NCT Number
- NCT00483782
- Trial Phase
- Phase III
Primary Outcome(s)
- Primary Outcome(s)
- PFS stratified for stage and risk of progression (High risk)
- Evaluated Outcome
- OS
- Form(s)
- Form 2a
Outcome Data
- PFS Control
- 10.5 months
- PFS Gain
- 5.5 months
- PFS HR
- 0.73 (0.60-0.93)
- OS Control
- 28.8 months
- OS Gain
- 7.8 months
- OS HR
- 0.64 (0.48-0.85)
Final Score (after adjustments)
- Preliminary non-curative score
-
3
- Final non-curative score
-
3
Scorecard details
- ESMO-MCBS version
- ESMO-MCBS v1.1
- Scorecard ID
- 39
- Scorecard version
- 1
- Issue date
- 11.12.2018
- Last update
- 10.10.2022
Legend
Information about symbols, abbrevations and color codes
- DFS
- Disease-Free Survival
- DoR
- Duration of Response
- EFS
- Event-Free Survival
- HR
- Hazard Ratio
- NEB
- No evaluable benefit
- NI
- Non-inferiority Study
- ORR
- Overall Response Rate
- OS
- Overall Surival
- pCR
- Pathological Complete Response/Remission
- PFS
- Progression-Free Survival
- QoL
- Quality of Life
- RFS
- Relapse-Free Survival
- RR
- Response Rate
QoL adjustments
Other adjustments*
Serious and disabling adverse effects
Red = negative / deterioration
Green = positive / improvement
Red = negative / deterioration
Green = positive / improvement
Red = negative / deterioration
Green = positive / improvement
Red = negative / deterioration
Green = positive / improvement
* Other adjustments include: