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4
ESMO-MCBS v1.1
Scorecard version: 1

Indication details

Tumour Type
Gynaecological Malignancies
Tumour Sub-type
Ovarian Cancer
Tumour stage
Metastatic
Combined Agent(s)
Chemotherapy
Control Arm
Paclitaxel or topotecan or liposomal doxorubicin
Treatment Setting
Recurrent platinum-resistant ovarian cancer
Trial Name
AURELIA

Primary Outcome(s)

Primary Outcome(s)
PFS (crossover allowed)
Form(s)
Form 2b

Outcome Data

PFS Control
3.4 months
PFS Gain
3.3 months
PFS HR
0.48 (0.38-0.60)
OS HR
NS
QoL Comment
Improved

Final Score (after adjustments)

Preliminary non-curative score
3
QoL adjustment
1+
Final non-curative Score
4

DFS, disease-free survival; DoR, duration of response; EFS, event-free survival; HR, hazard ratio; ORR, overall response rate; OS, overall survival; pCR, pathologic complete response/remission; PFS, progression-free survival; QoL, quality of life; RFS, relapse-free survival; RR, response rate

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