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2
ESMO-MCBS v1.1
Scorecard version: 1

Indication details

Tumour Type
Gastrointestinal Cancers
Tumour Sub-type
Gastric or gastro-oesophageal junction adenocarcinoma
Tumour stage
Metastatic
Combined Agent(s)
Paclitaxel
Control Arm
Paclitaxel + placebo
Treatment Setting
2nd line advanced or metastatic gastric or EGJ adenocarcinoma
Trial Name
RAINBOW

Primary Outcome(s)

Primary Outcome(s)
OS
Evaluated Outcome
OS
Form(s)
Form 2a

Outcome Data

OS Control
7.4 months
OS Gain
2.2 months
OS HR
0.81 (0.68-0.96)
QoL Comment
No benefit observed

Final Score (after adjustments)

Preliminary non-curative score
2
Final non-curative Score
2
Issue date
11.12.2018
Last update
05.11.2020

ChT; chemotherapy; DFS, disease-free survival; DoR, duration of response; EFS, event-free survival; FFS, failure-free survival; HR, hazard ratio; iDFS, invasive disease-free survival; ITT, intention to treat; MFS, metastasis-free survival; ORR, overall response rate; OS, overall survival; pCR, pathologic complete response/remission; PE, point estimate; PFS, progression-free survival; QoL, quality of life; RFS, relapse-free survival; RR, response rate; SD, stable disease; SSA, somatostatin analogue; SSTR, somatostatin receptor; TKI, tyrosine kinase inhibitor, TTP, time to progression

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