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3
ESMO-MCBS v1.1
Scorecard version: 1

Indication details

Tumour Type
Thoracic Malignancies
Tumour Sub-type
Non-small-cell Lung Cancer
Tumour Sub-Group
Refractory NTRK fusion–positive cancers
Tumour stage
Advanced
Control Arm
Single arm
Treatment Setting
Treatment of adult patients with ROS1-positive, advanced non-small cell lung cancer (NSCLC) not previously treated with ROS1 inhibitors

Primary Outcome(s)

Primary Outcome(s)
ORR, DOR
Evaluated Outcome
ORR, DOR
Form(s)
Form 3

Outcome Data

PFS Control
19.0 months
ORR
77%
DoR
24.6 months

Final Score (after adjustments)

Preliminary non-curative score
3
Final non-curative Score
3
Issue date
23.07.2020
Release date
23.07.2020

DFS, disease-free survival; DoR, duration of response; EFS, event-free survival; FFS, failure-free survival; HR, hazard ratio; iDFS, invasive disease-free survival; ITT, intention to treat; MFS, metastasis-free survival; ORR, overall response rate; OS, overall survival; pCR, pathologic complete response/remission; PFS, progression-free survival; QoL, quality of life; RFS, relapse-free survival; RR, response rate; SD, stable disease; SSA, somatostatin analogue; SSTR, somatostatin receptor; TKI, tyrosine kinase inhibitor, TTP, time to progression

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