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3
ESMO-MCBS v1.1
Scorecard version: 1

Indication details

Tumour Type
Thoracic Malignancies
Tumour Sub-type
Non-small-cell Lung Cancer
Tumour Sub-Group
ROS1+
Tumour stage
Advanced
Control Arm
Single arm study
Treatment Setting
Cohort study 50 patients (86% had received at least one previous line of standard therapy)

Primary Outcome(s)

Primary Outcome(s)
ORR and mPFS (Phase I)
Form(s)
Form 3

Outcome Data

ORR
72% achieved in ORR (95% CI 58-84), mPFS 19.2 months (95% CI 14.4 - not reached)

Final Score (after adjustments)

Preliminary non-curative score
3
Final non-curative Score
3
Release date
16.05.2019

DFS, disease-free survival; DoR, duration of response; EFS, event-free survival; HR, hazard ratio; ORR, overall response rate; OS, overall survival; pCR, pathologic complete response/remission; PFS, progression-free survival; QoL, quality of life; RFS, relapse-free survival; RR, response rate

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