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FLOT (docetaxel, oxaliplatin, fluorouracil and leucovorin)

A
ESMO-MCBS v1.1
Scorecard version: 1

Indication details

Tumour Type
Gastrointestinal Cancers
Tumour Sub-type
Gastric or gastro-oesophageal junction adenocarcinoma
Tumour stage
Locally advanced
Control Arm
Fluorouracil or capecitabine plus cisplatin and epirubicin
Treatment Setting
Peri-operative locally advanced, resectable gastric or gastroesophageal junction adenocarcinoma
Trial Name
FLOT4

Primary Outcome(s)

Primary Outcome(s)
OS (Phase II/III)
Form(s)
Form 1

Outcome Data

OS Control
35 months (median) OS at 3 years: 48%
OS Gain
15 months (median) OS at 3 years: 9%
OS HR
0.77 (0.63–0.94)
Toxicity Comment
Adverse advents similar

Final Score (after adjustments)

Final curative score
A
Release date
03.05.2019
Last update
08.02.2022

ChT; chemotherapy; DFS, disease-free survival; DoR, duration of response; EFS, event-free survival; FFS, failure-free survival; HR, hazard ratio; iDFS, invasive disease-free survival; ITT, intention to treat; MFS, metastasis-free survival; NS; not significant; ORR, overall response rate; OS, overall survival; pCR, pathologic complete response/remission; PE, point estimate; PFS, progression-free survival; QoL, quality of life; RFS, relapse-free survival; RR, response rate; SD, stable disease; SSA, somatostatin analogue; SSTR, somatostatin receptor; TKI, tyrosine kinase inhibitor, TTP, time to progression

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