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  1. ESMO
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  4. ESMO-MCBS for Solid Tumours

ESMO-MCBS Scorecards

ESMO MCBS 1000x150

The ESMO-MCBS Scorecards provides a centralised location of cancer medicines approved by the European Medicines Agency and the US Food and Drug Administration that have been scored and published by ESMO.

ESMO-MCBS scores are based on peer reviewed clinical trial reports. They are generated using a validated standard methodology and are reviewed by a team of clinicians and statisticians before publication. ESMO-MCBS scores should be interpreted in the context of an evolving treatment landscape, in connection with clinical practice guidelines.

ESMO-MCBS Scores
Number of studies
Non-curative setting
5 22
4 135
3 161
2 55
1 24
NEB 4
Curative setting
A 59
C 3
NEB 3
ESMO-MCBS Scores by tumour type
Non-curative setting
Brain Tumours 4
Breast Cancer 39
Endocrine Tumours 23
Gastrointestinal Cancers 76
Genitourinary Cancers 71
Gynaecological Malignancies 38
Head and neck cancer 12
Non-cancerous soft-tissue tumour 3
Sarcoma 13
Skin Cancers 29
Thoracic Malignancies 86
TMB-H solid tumours 1
Tumour agnostic 6
Curative setting
Brain Tumours 2
Breast Cancer 9
Endocrine Tumours 0
Gastrointestinal Cancers 17
Genitourinary Cancers 5
Gynaecological Malignancies 1
Head and neck cancer 1
Non-cancerous soft-tissue tumour 0
Sarcoma 3
Skin Cancers 14
Thoracic Malignancies 13
TMB-H solid tumours 0
Tumour agnostic 0

The ESMO-MCBS Scorecards

reset selection
Evaluation form 1  For new approaches to adjuvant therapy or new potentially curative therapies
Evaluation form 2a For therapies that are not likely to be curative with primary endpoint of OS with separate sheets for:
Evaluation form 2b For therapies that are not likely to be curative with primary endpoint PFS with separate sheets for:
Evaluation form 2c  For therapies that are not likely to be curative with primary endpoint other than OS or PFS or equivalent (non-inferiority) studies
Evaluation form 3  For single-arm studies in orphan diseases and for diseases with high unmet need when primary outcome is PFS or ORR.
To evaluate ESMO-MCBS score adjustments based on quality of life .

My watchlist

    Tested Agent(s) Combined Agent(s) Control Arm Therapeutic Indication Tumour Type Tumour Sub-type Tumour Sub-group Trial Name Ref. Score Scorecard Scorecard
    Nivolumab Fluoropyrimidine + platinum ChT (FOLFOX or CAPOX) ChT (FOLFOX or CAPOX) Treatment for adult patients with advanced or metastatic gastric cancer, gastroesophageal junction cancer and oesophageal adenocarcinoma CheckMate 649
    Gastrointestinal Cancers
    		 Gastric or gastroesophageal junction cancer and oesophageal adenocarcinoma - CheckMate 649

    1

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a
      1
    Nivolumab Fluoropyrimidine + platinum ChT (FOLFOX or CAPOX) ChT (FOLFOX or CAPOX) First‑line treatment for patients with HER2‑negative advanced or metastatic gastric, gastroesophageal junction or oesophageal adenocarcinoma whose tumours express PD-L1 with a CPS ≥5 CheckMate 649
    Gastrointestinal Cancers
    		 Gastric or gastroesophageal junction cancer and oesophageal adenocarcinoma HER2- PD-L1 CPS ≥5 CheckMate 649

    4

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a
      4
    Pralsetinib - Single arm Treatment for adult patients with metastatic rearranged during transfection (RET) fusion-positive non-small cell lung cancer (NSCLC) as detected by an FDA-approved test ARROW
    Thoracic Malignancies
    		 Non-small-cell Lung Cancer RET fusion-positive ARROW

    3

    PRELIMINARY SCORE

    • ORR

    ADJUSTMENTS

    SCORE

    • F3
      3
    Pralsetinib - Single arm Treatment for adult patients with metastatic RET fusion-positive non-small cell lung cancer (NSCLC) not previously treated with a RET inhibitor ARROW
    Breast Cancer
    		 Non-small-cell Lung Cancer RET fusion-positive ARROW

    3

    PRELIMINARY SCORE

    • ORR

    ADJUSTMENTS

    SCORE

    • F3
      3
    Pembrolizumab - Single arm cohort study Patients with unresectable or metastatic dMMR/MSI-H solid tumours that have progressed following prior treatment and have no alternative treatment options KEYNOTE-158 - Cohort K
    Tumour agnostic
    		 - dMMR/MSI-H KEYNOTE-158 - Cohort K

    3

    PRELIMINARY SCORE

    • ORR

    ADJUSTMENTS

    SCORE

    • F3
      3
    Trastuzumab ChT (cisplatin + capecitabine or 5-FU) ChT HER2-positive metastatic adenocarcinoma of the stomach or gastroesophageal junction in patients who have not received prior anti-cancer treatment for their metastatic disease ToGA
    Gastrointestinal Cancers
    		 Stomach or gastroesophageal junction cancer HER2+ ToGA

    3

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a
      3
    Ivosidenib - Placebo For adult patients with locally advanced or metastatic cholangiocarcinoma with an IDH1 R132 mutation who were previously treated by at least one prior line of systemic therapy. ClarIDHy
    Gastrointestinal Cancers
    		 Cholangiocarcinoma IDH1 ClarIDHy

    2

    PRELIMINARY SCORE

    • PFS

    ADJUSTMENTS

    SCORE

    • F2b
      2
    Mobocertinib - Single arm Locally advanced or metastatic NSCLC with EGFR exon 20 insertion mutations, with progression on or after platinum-based ChT Study 101
    Thoracic Malignancies
    		 Non-small-cell Lung Cancer EGFR+ exon 20 insertion mutations Study 101

    2

    PRELIMINARY SCORE

    • ORR

    ADJUSTMENTS

    SCORE

    • F3
      2
    Tisotumab vedotin - Single arm (Phase II) Adult patients with recurrent or metastatic cervical cancer with disease progression on or after ChT innovaTV 204
    Gynaecological Malignancies
    		 Cervical Cancer - innovaTV 204

    2

    PRELIMINARY SCORE

    • ORR

    ADJUSTMENTS

    SCORE

    • F3
      2
    Trifluridine/Tipiracil (TAS-102) - Placebo Treatment of patients with mCRC in patients who have been previously treated with, or are not considered candidates for, available therapies including fluoropyrimidine-, oxaliplatin- and irinotecan-based ChT, anti-VEGF agents and anti-EGFR agents RECOURSE
    Gastrointestinal Cancers
    		 Colorectal Cancer - RECOURSE

    3

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a
      3
    Pembrolizumab - ChT (5-fluorouracil–based therapy with or without bevacizumab or cetuximab) First-line treatment of adults with MSI-H or dMMR mCRC KEYNOTE-177
    Gastrointestinal Cancers
    		 Colorectal Cancer dMMR+ or MSI-H+ KEYNOTE-177

    4

    PRELIMINARY SCORE

    • PFS

    ADJUSTMENTS

    SCORE

    • F2b
      4
    Cabozantinib - Placebo Treatment of adult patients with locally advanced or metastatic differentiated thyroid carcinoma, refractory or not eligible to radioactive iodine who have progressed during or after prior systemic therapy COSMIC-311
    Endocrine Tumours
    		 Thyroid cancer - differentiated - COSMIC-311

    2

    PRELIMINARY SCORE

    • PFS

    ADJUSTMENTS

    SCORE

    • F2b
      2
    Pralsetinib - Single arm Adult and pediatric patients 12 years of age and older with advanced or metastatic RET-mutant MTC who require systemic therapy ARROW
    Endocrine Tumours
    		 Thyroid Cancer - medullary RET-mutant ARROW

    3

    PRELIMINARY SCORE

    • ORR

    ADJUSTMENTS

    SCORE

    • F3
      3
    Pralsetinib - Single arm Adult and paediatric patients 12 years of age and older with advanced or metastatic RETfusion-positive thyroid cancer who require systemic therapy and who are RAI-refractory ARROW
    Endocrine Tumours
    		 Thyroid cancer - differentiated RET fusion-positive ARROW

    3

    PRELIMINARY SCORE

    • ORR

    ADJUSTMENTS

    SCORE

    • F3
      3
    Atezolizumab - Best supportive care Adjuvant treatment following resection and platinum-based ChT for adult patients with Stage II to IIIA NSCLC whose tumors have PD-L1 expression on ≥1% of tumor cells IMpower010
    Thoracic Malignancies
    		 Non-small-cell Lung Cancer PD-L1 ≥1% IMpower010

    A

    PRELIMINARY SCORE

    • DFS

    ADJUSTMENTS

    SCORE

    • F1

      A
    Pembrolizumab ChT with our without bevacizumab Placebo + ChT with our without bevacizumab Persistent, recurrent, or metastatic cervical cancer in adults whose tumours express PD-L1 with a CPS ≥1 KEYNOTE-826
    Gynaecological Malignancies
    		 Cervical Cancer PD-L1 (CPS ≥1) KEYNOTE-826

    4

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a
      4
    Pembrolizumab Cisplatin + 5-FU Placebo + cisplatin + 5-FU First-line treatment locally advanced or metastatic oesophageal or gastroesophageal junction carcinoma that is not amenable to surgical resection or definitive CRT in combination with platinum- and fluoropyrimidine-based ChT KEYNOTE-590
    Gastrointestinal Cancers
    		 Oesophageal or gastroesophageal junction carcinoma HER2- GEJ (all randomized) KEYNOTE-590

    4

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a
      4
    Pembrolizumab Cisplatin + 5-FU Placebo + cisplatin + 5-FU Pembrolizumab in combination with platinum and fluoropyrimidine-based chemotherapy, is indicated for the first-line treatment of locally advanced unresectable or metastatic carcinoma of the oesophagus in adults whose tumours express PD-L1 with a CPS ≥ 10 KEYNOTE-590
    Gastrointestinal Cancers
    		 Oesophageal squamous cell carcinoma PD-L1 CPS ≥10 KEYNOTE-590

    4

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a
      4
    Pembrolizumab Cisplatin and 5-FU ChT Placebo + cisplatin and 5-FU ChT First-line treatment KEYNOTE-590
    Gastrointestinal Cancers
    		 Oesophageal squamous cell carcinoma HER2- GEJ (squamous cell) KEYNOTE-590

    3

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a
      3
    Pembrolizumab Cisplatin and 5-FU ChT Placebo + cisplatin and 5-FU ChT First-line treatment KEYNOTE-590
    Gastrointestinal Cancers
    		 Oesophageal squamous cell carcinoma HER2- GEJ PD-L1 (squamous cell) CPS ≥10 KEYNOTE-590

    4

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a
      4
    Nab-sirolimus - Single arm Nab-sirolimus for the efficacy in Patients With Advanced Malignant Perivascular Epithelioid Cell Tumors (PEComa). AMPECT
    Sarcoma
    		 Perivascular epithelioid - AMPECT

    3

    PRELIMINARY SCORE

    • ORR

    ADJUSTMENTS

    SCORE

    • F3
      3
    Pembrolizumab - Placebo Adjuvant treatment of adults with RCC at increased risk of recurrence following nephrectomy, or following nephrectomy and resection of metastatic lesions KEYNOTE-564
    Genitourinary Cancers
    		 Renal cell cancer - KEYNOTE-564

    A

    PRELIMINARY SCORE

    • DFS

    ADJUSTMENTS

    SCORE

    • F1

      A
    Belzutifan - Single arm EMA: Belzutifan as monotherapy for the treatment of adult patients with von Hippel-Lindau disease who require therapy for associated, localised renal cell carcinoma (RCC), central nervous system (CNS) haemangioblastomas, or pancreatic neuroendocrine tumours (pNET), and for whom localised procedures are unsuitable. FDA: For adult patients with von Hippel-Lindau (VHL) disease who require therapy for associated renal cell carcinoma (RCC), central nervous system (CNS) hemangioblastomas, or pancreatic neuroendocrine tumors (pNET), not requiring immediate surgery. MK-6482 (Study 004)
    Genitourinary Cancers
    		 von Hippel-Lindau disease-associated Renal Cell Carcinoma - MK-6482 (Study 004)

    3

    PRELIMINARY SCORE

    • ORR

    ADJUSTMENTS

    SCORE

    • F3
      3
    FOLFOX (folinic acid, fluorouracil, oxaliplatin) - Symptomatic care Second-line treatment of advanced biliary tract cancer ABC-06
    Gastrointestinal Cancers
    		 Biliary tract cancer - ABC-06

    1

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a
      1
    Tebentafusp - Investigator Choice (either dacarbazine, ipilimumab or pembrolizumab) Treatment of human leukocyte antigen (HLA)-A*02:01-positive adult patients with unresectable or metastatic uveal melanoma IMCgp100-202
    Skin Cancers
    		 Uveal melanoma HLA-A*0201positive IMCgp100-202

    4

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a
      4
    Amivantamab - Single arm Advanced NSCLC with activating EGFR exon 20 insertion mutations, after failure of platinum-based therapy CHRYSALIS
    Thoracic Malignancies
    		 Non-small-cell Lung Cancer EGFR+ exon 20 insertion mutations CHRYSALIS

    3

    PRELIMINARY SCORE

    • ORR

    ADJUSTMENTS

    SCORE

    • F3
      3
    Pembrolizumab Trastuzumab, fluoropyrimidine + platinum-containing ChT Placebo + trastuzumab, fluoropyrimidine + platinum-containing ChT EMA: Pembrolizumab for the first-line treatment of locally advanced unresectable or metastatic HER2-positive gastric or gastroesophageal junction adenocarcinoma in adults whose tumours express PD-L1 with a CPS ≥1. FDA: Pembrolizumab in combination with trastuzumab, fluoropyrimidine- and platinum-containing chemotherapy for the first-line treatment of patients with locally advanced unresectable or metastatic HER2 positive gastric or gastroesophageal junction (GEJ) adenocarcinoma whose tumors express PD-L1 (CPS ≥1). KEYNOTE-811
    Gastrointestinal Cancers
    		 Gastric or gastroesophageal junction adenocarcinoma HER-2 positive KEYNOTE-811

    3

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a
      3
    Pembrolizumab - Single arm cohort study Patients with unresectable of metastatic TMB-H solid tumours that have progressed following prior treatment and have no alternative treatment options KEYNOTE-158
    TMB-H solid tumours
    		 - TMB-H KEYNOTE-158

    3

    PRELIMINARY SCORE

    • ORR

    ADJUSTMENTS

    SCORE

    • F3
      3
    Pembrolizumab - Single arm cohort study (Phase II) Patients with advanced or recurrent dMMR/MSI-H endometrial carcinoma who have disease progression on or following prior treatment with a platinum-containing therapy in any setting and who are not candidates for curative surgery or radiation KEYNOTE-158
    Gynaecological Malignancies
    		 Endometrial Cancer dMMR/MSI-H KEYNOTE-158

    3

    PRELIMINARY SCORE

    • ORR

    ADJUSTMENTS

    SCORE

    • F3
      3
    Relugolix - Leuprolide Treatment of adult patients with advanced HSPC HERO
    Genitourinary Cancers
    		 Prostate cancer - HERO

    4

    PRELIMINARY SCORE

    • NI

    ADJUSTMENTS

    SCORE

    • F2c
      4

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