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  4. ESMO-MCBS for Solid Tumours

ESMO-MCBS Scorecards

ESMO MCBS 1000x150

The ESMO-MCBS Scorecards provides a centralised location of cancer medicines approved by the European Medicines Agency and the US Food and Drug Administration that have been scored and published by ESMO.

ESMO-MCBS scores are based on peer reviewed clinical trial reports. They are generated using a validated standard methodology and are reviewed by a team of clinicians and statisticians before publication. ESMO-MCBS scores should be interpreted in the context of an evolving treatment landscape, in connection with clinical practice guidelines.

ESMO-MCBS Scores
Number of studies
Non-curative setting
5 22
4 135
3 161
2 55
1 24
NEB 4
Curative setting
A 59
C 3
NEB 3
ESMO-MCBS Scores by tumour type
Non-curative setting
Brain Tumours 4
Breast Cancer 39
Endocrine Tumours 23
Gastrointestinal Cancers 76
Genitourinary Cancers 71
Gynaecological Malignancies 38
Head and neck cancer 12
Non-cancerous soft-tissue tumour 3
Sarcoma 13
Skin Cancers 29
Thoracic Malignancies 86
TMB-H solid tumours 1
Tumour agnostic 6
Curative setting
Brain Tumours 2
Breast Cancer 9
Endocrine Tumours 0
Gastrointestinal Cancers 17
Genitourinary Cancers 5
Gynaecological Malignancies 1
Head and neck cancer 1
Non-cancerous soft-tissue tumour 0
Sarcoma 3
Skin Cancers 14
Thoracic Malignancies 13
TMB-H solid tumours 0
Tumour agnostic 0

The ESMO-MCBS Scorecards

reset selection
Evaluation form 1  For new approaches to adjuvant therapy or new potentially curative therapies
Evaluation form 2a For therapies that are not likely to be curative with primary endpoint of OS with separate sheets for:
Evaluation form 2b For therapies that are not likely to be curative with primary endpoint PFS with separate sheets for:
Evaluation form 2c  For therapies that are not likely to be curative with primary endpoint other than OS or PFS or equivalent (non-inferiority) studies
Evaluation form 3  For single-arm studies in orphan diseases and for diseases with high unmet need when primary outcome is PFS or ORR.
To evaluate ESMO-MCBS score adjustments based on quality of life .

My watchlist

    Tested Agent(s) Combined Agent(s) Control Arm Therapeutic Indication Tumour Type Tumour Sub-type Tumour Sub-group Trial Name Ref. Score Scorecard Scorecard
    Dostarlimab - Single arm EMA: As monotherapy for the treatment of adult patients with mismatch repair deficient (dMMR)/microsatellite instability-high (MSI-H) recurrent or advanced endometrial cancer (EC) that has progressed on or following prior treatment with a platinum-containing regimen.. FDA: Treatment of adult patients with mismatch repair deficient (dMMR) recurrent or advanced endometrial cancer, that has progressed on or following a prior platinum-containing regimen in any setting and are not candidates for curative surgery or radiation. GARNET
    Gynaecological Malignancies
    		 Endometrial Cancer dMMR or MSI-H GARNET

    3

    PRELIMINARY SCORE

    • ORR

    ADJUSTMENTS

    SCORE

    • F3
      3
    Nivolumab + ipilimumab 2 cycles of platinum-based ChT Chemotherapy First line treatment of mNSCLC with no sensitising EGFR mutation or ALK translocation CheckMate-9LA
    Thoracic Malignancies
    		 Non-small-cell Lung Cancer - CheckMate-9LA

    4

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a
      4
    5-FU/LV (fluorouracil + leucovorin) - Lomustine (MeCCNU) + vincristine + 5-FU Patients with Dukes' stage B and C colon cancer NSABP C-03
    Gastrointestinal Cancers
    		 Colon Cancer - NSABP C-03

    A

    PRELIMINARY SCORE

    • DFS

    ADJUSTMENTS

    SCORE

    • F1

      A
    5-FU (fluorouracil) Folinic acid Observation Patients with surgically resected colon cancer in Dukes' stage C
    Gastrointestinal Cancers
    		 Colon Cancer - -

    A

    PRELIMINARY SCORE

    • DFS

    ADJUSTMENTS

    SCORE

    • F1

      A
    5-FU/LV (fluorouracil + leucovorin) - Observation High-risk stage II or stage III colon cancer NCCTG 874651
    Gastrointestinal Cancers
    		 Colon Cancer - NCCTG 874651

    A

    PRELIMINARY SCORE

    • DFS

    ADJUSTMENTS

    SCORE

    • F1

      A
    5-FU (fluorouracil) Folinic acid Surgery alone Patients with resectable Dukes B and C (AJCC/UICC Stage II and Stage III) colon carcinoma GIVIO-SITAC 01
    Gastrointestinal Cancers
    		 Colon Cancer - GIVIO-SITAC 01

    A

    PRELIMINARY SCORE

    • DFS

    ADJUSTMENTS

    SCORE

    • F1

      A
    5-FU/LV (fluorouracil + leucovorin) or 5-FU/LEV (fluorouracil + levamisole) - Surgery alone (Meta-analysis) Patients with stage II and III colon cancer (ITT and age stratified including >70 years)
    Gastrointestinal Cancers
    		 Colon Cancer - -

    A

    PRELIMINARY SCORE

    • DFS

    ADJUSTMENTS

    SCORE

    • F1

      A
    5-FU/LV (fluorouracil + leucovorin) or 5-FU/LEV (fluorouracil + levamisole) - Surgery alone (Pooled-analysis) Patients with stage II and III colon cancer
    Gastrointestinal Cancers
    		 Colon Cancer - -

    A

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F1

      A
    5-FU/LV (fluorouracil + leucovorin) or 5-FU/LEV (fluorouracil + levamisole) - Surgery alone (Meta-analysis) Patients with resected stage II and III colon cancer
    Gastrointestinal Cancers
    		 Colon Cancer - -

    A

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F1

      A
    5-FU/LV (fluorouracil + leucovorin) or 5-FU/LEV (fluorouracil + levamisole) - Surgery alone (Meta-analysis) Patients with resected stage II and III colon cancer
    Gastrointestinal Cancers
    		 Colon Cancer - -

    A

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F1

      A
    5FU/LEV (5-fluorouracil + levamisole) - Levamisole Resected stage III (Dukes stage C) colon cancer Intergroup 0035
    Gastrointestinal Cancers
    		 Colon Cancer - Intergroup 0035

    A

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F1

      A
    Tivozanib - Sorafenib Adult patients with relapsed or refractory advanced RCC following ≥2 prior systemic therapies TIVO-3
    Genitourinary Cancers
    		 Renal cell cancer - TIVO-3

    3

    PRELIMINARY SCORE

    • PFS

    ADJUSTMENTS

    SCORE

    • F2b
      3
    Enzalutamide ADT (androgen deprivation therapy) Placebo + ADT For the treatment of adult men with metastatic hormone-sensitive prostate cancer (mHSPC) in combination with androgen deprivation therapy ARCHES
    Genitourinary Cancers
    		 Prostate cancer - ARCHES

    3

    PRELIMINARY SCORE

    • PFS

    ADJUSTMENTS

    SCORE

    • F2b
      3
    Lorlatinib - Crizotinib Treatment of adult patients with anaplastic lymphoma kinase (ALK) positive (NSCLC) previously not treated with an ALK inhibitor CROWN
    Thoracic Malignancies
    		 Non-small-cell Lung Cancer ALK+ CROWN

    4

    PRELIMINARY SCORE

    • PFS

    ADJUSTMENTS

    SCORE

    • F2b
      4
    Sacituzumab govitecan - Physician’s choice of single agent ChT Treatment of patients with unresectable or metastatic TNBC who have received ≥2 prior systemic therapies, ≥1 of them for advanced disease ASCENT
    Breast Cancer
    		 Breast Cancer Triple-negative ASCENT

    5

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a
      5
    Nivolumab Cabozantinib Sunitinib First-line treatment of adult patients with advanced RCC CheckMate-9ER
    Genitourinary Cancers
    		 Renal cell cancer - CheckMate-9ER

    1

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a
      1
    Atezolizumab - Single arm (Phase II) Single-arm study of atezolizumab in patients with locally advanced or metastatic urothelial bladder cancer IMvigor210 (Cohort 2)
    Genitourinary Cancers
    		 Urothelial Carcinoma - IMvigor210 (Cohort 2)

    1

    PRELIMINARY SCORE

    • ORR

    ADJUSTMENTS

    SCORE

    • F3
      1
    Enfortumab vedotin - Single arm (Phase II) Patients with locally advanced or metastatic UC who are ineligible for cisplatin-containing ChT and have previously received ≥1 prior lines of therapy EV-201 - Cohort 2
    Genitourinary Cancers
    		 Urothelial Carcinoma - EV-201 - Cohort 2

    3

    PRELIMINARY SCORE

    • ORR

    ADJUSTMENTS

    SCORE

    • F3
      3
    Erdafitinib - Single arm (Phase II) Locally advanced or metastatic urothelial carcinoma with susceptible FGFR3 or FGFR2 genetic alterations and disease progression during/after ≥1 prior platinum-containing ChT BLC2001
    Genitourinary Cancers
    		 Urothelial Carcinoma FGFR3 or FGFR2 genetic alterations BLC2001

    1

    PRELIMINARY SCORE

    • ORR

    ADJUSTMENTS

    SCORE

    • F3
      1
    Pembrolizumab - Single arm Locally advanced or metastatic UC in adults who are not eligible for cisplatin-containing ChT and whose tumours express PD-L1 with a CPS ≥10 KEYNOTE-052
    Genitourinary Cancers
    		 Urothelial Carcinoma PD-L1 CPS ≥10% KEYNOTE-052

    3

    PRELIMINARY SCORE

    • ORR

    ADJUSTMENTS

    SCORE

    • F3
      3
    Pembrolizumab - Investigator’s choice of ChT (paclitaxel, docetaxel or vinflunine) Locally advanced or metastatic UC in adults who have received prior platinum-containing ChT KEYNOTE-045
    Genitourinary Cancers
    		 Urothelial Carcinoma - KEYNOTE-045

    A

    4

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a/F1
      4

      A
    Nivolumab - Placebo Adjuvant therapy for adult patients with oesophageal or gastroesophageal junction cancer who have residual pathologic disease following prior neoadjuvant chemoradiotherapy CheckMate 577
    Gastrointestinal Cancers
    		 Oesophageal or gastroesophageal junction carcinoma - CheckMate 577

    A

    PRELIMINARY SCORE

    • DFS

    ADJUSTMENTS

    SCORE

    • F1

      A
    Sotorasib - Single arm Treatment of adults with advanced non-small cell lung cancer with KRAS G12C mutation and who have progressed after at least one prior line of systemic therapy CodeBreaK 100
    Thoracic Malignancies
    		 Non-small-cell Lung Cancer KRAS G12C mutated CodeBreaK 100

    3

    PRELIMINARY SCORE

    • ORR

    ADJUSTMENTS

    SCORE

    • F3
      3
    Cemiplimab - Single arm (Phase II) Treatment of basal cell carcinoma (laBCC or mBCC) who have progressed on or are intolerant to a hedgehog pathway inhibitor (HHI) Study 1620
    Skin Cancers
    		 Basal Cell Carcinoma - Study 1620

    3

    PRELIMINARY SCORE

    • ORR

    ADJUSTMENTS

    SCORE

    • F3
      3
    Nivolumab + ipilimumab - Single arm FDA: Treatment of adult patients with dMMR or MSI-H mCRC after prior fluoropyrimidine-based combination ChT. EMA: Nivolumab in combination with ipilimumab for the treatment adult patients with dMMR or MSI-H colorectal cancer after prior fluoropyrimidine based combination chemotherapy CheckMate142
    Gastrointestinal Cancers
    		 Colorectal Cancer dMMR+ or MSI-H+ CheckMate142

    3

    PRELIMINARY SCORE

    • ORR

    ADJUSTMENTS

    SCORE

    • F3
      3
    Pemetrexed Cisplatin Cisplatin In combination with cisplatin for the treatment of chemotherapy naïve patients with unresectable malignant pleural mesothelioma EMPHACIS
    Thoracic Malignancies
    		 Pleural mesothelioma - EMPHACIS

    3

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a
      3
    Lenvatinib Pembrolizumab Sunitinib Treatment of adults with advanced renal cell carcinoma in combination with pembrolizumab as first-line treatment CLEAR
    Genitourinary Cancers
    		 Renal cell cancer - CLEAR

    4

    PRELIMINARY SCORE

    • PFS

    ADJUSTMENTS

    SCORE

    • F2b
      4
    Pembrolizumab ChT (paclitaxel + carboplatin) Placebo plus ChT (paclitaxel + carboplatin) In combination with ChT as neoadjuvant treatment and then continued as monotherapy as adjuvant treatment after surgery, is indicated for the treatment of adults with locally advanced, or early‑stage triple‑negative breast cancer at high risk of recurrence KEYNOTE-522
    Breast Cancer
    		 Early Breast Cancer Triple-negative KEYNOTE-522

    A

    PRELIMINARY SCORE

    • DFS

    ADJUSTMENTS

    SCORE

    • F1

      A
    Enfortumab vedotin - Investigator-chosen ChT (standard docetaxel, paclitaxel or vinflunine) Treatment of adult patients with locally advanced or metastatic urothelial cancer who have previously received a platinum-containing chemotherapy and a programmed death receptor-1 or programmed death-ligand 1 inhibitor EV-301
    Genitourinary Cancers
    		 Urothelial Carcinoma - EV-301

    4

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a
      4
    Pembrolizumab - Single arm Bacillus Calmette-Guerin (BCG)-unresponsive, high-risk, non-muscle invasive bladder cancer (NMIBC) with carcinoma in situ (CIS) with or without papillary tumors who are ineligible for or have elected not to undergo cystectomy KEYNOTE-057
    Genitourinary Cancers
    		 Urothelial Carcinoma - KEYNOTE-057

    3

    PRELIMINARY SCORE

    • ORR

    ADJUSTMENTS

    SCORE

    • F3
      3

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