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  1. ESMO
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  4. ESMO-MCBS for Solid Tumours

ESMO-MCBS Scorecards

ESMO MCBS 1000x150

The ESMO-MCBS Scorecards provides a centralised location of cancer medicines approved by the European Medicines Agency and the US Food and Drug Administration that have been scored and published by ESMO.

ESMO-MCBS scores are based on peer reviewed clinical trial reports. They are generated using a validated standard methodology and are reviewed by a team of clinicians and statisticians before publication. ESMO-MCBS scores should be interpreted in the context of an evolving treatment landscape, in connection with clinical practice guidelines.

ESMO-MCBS Scores
Number of studies
Non-curative setting
5 22
4 135
3 161
2 55
1 24
NEB 4
Curative setting
A 59
C 3
NEB 3
ESMO-MCBS Scores by tumour type
Non-curative setting
Brain Tumours 4
Breast Cancer 39
Endocrine Tumours 23
Gastrointestinal Cancers 76
Genitourinary Cancers 71
Gynaecological Malignancies 38
Head and neck cancer 12
Non-cancerous soft-tissue tumour 3
Sarcoma 13
Skin Cancers 29
Thoracic Malignancies 86
TMB-H solid tumours 1
Tumour agnostic 6
Curative setting
Brain Tumours 2
Breast Cancer 9
Endocrine Tumours 0
Gastrointestinal Cancers 17
Genitourinary Cancers 5
Gynaecological Malignancies 1
Head and neck cancer 1
Non-cancerous soft-tissue tumour 0
Sarcoma 3
Skin Cancers 14
Thoracic Malignancies 13
TMB-H solid tumours 0
Tumour agnostic 0

The ESMO-MCBS Scorecards

reset selection
Evaluation form 1  For new approaches to adjuvant therapy or new potentially curative therapies
Evaluation form 2a For therapies that are not likely to be curative with primary endpoint of OS with separate sheets for:
Evaluation form 2b For therapies that are not likely to be curative with primary endpoint PFS with separate sheets for:
Evaluation form 2c  For therapies that are not likely to be curative with primary endpoint other than OS or PFS or equivalent (non-inferiority) studies
Evaluation form 3  For single-arm studies in orphan diseases and for diseases with high unmet need when primary outcome is PFS or ORR.
To evaluate ESMO-MCBS score adjustments based on quality of life .

My watchlist

    Tested Agent(s) Combined Agent(s) Control Arm Therapeutic Indication Tumour Type Tumour Sub-type Tumour Sub-group Trial Name Ref. Score Scorecard Scorecard
    Crizotinib - Single arm Treatment of adults with ROS1-positive advanced non-small cell lung cancer (NSCLC) PROFILE 1001
    Thoracic Malignancies
    		 Non-small-cell Lung Cancer ROS1+ PROFILE 1001

    3

    PRELIMINARY SCORE

    • ORR

    ADJUSTMENTS

    SCORE

    • F3
      3
    Dab/Tram (dabrafenib and trametinib) - Single arm Advanced NSCLC with a BRAF V600 mutation
    Thoracic Malignancies
    		 Non-small-cell Lung Cancer BRAF V600E (Pretreated (Cohort B)) -

    2

    PRELIMINARY SCORE

    • ORR

    ADJUSTMENTS

    SCORE

    • F3
      2
    Dab/Tram (dabrafenib and trametinib) - Single arm Advanced NSCLC with a BRAF V600 mutation
    Thoracic Malignancies
    		 Non-small-cell Lung Cancer BRAF V600E (Treatment-naïve (Cohort C)) -

    2

    PRELIMINARY SCORE

    • ORR

    ADJUSTMENTS

    SCORE

    • F3
      2
    Pembrolizumab Pemetrexed + platinum chemotherapy Placebo + pemetrexed + platinum chemotherapy In combination with pemetrexed and platinum chemotherapy for the first-line treatment of metastatic non-squamous non-small cell lung carcinoma in adults whose tumours have no EGFR or ALK positive tumour mutations KEYNOTE-189
    Thoracic Malignancies
    		 Non-small-cell Lung Cancer - KEYNOTE-189

    A

    4

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a/F1
      4

      A
    Pertuzumab Standard adjuvant ChT + 1 year of treatment with trastuzumab Placebo + standard adjuvant ChT + 1 year of treatment with trastuzumab Adjuvant treatment of adult patients with HER2-positive early breast cancer at high risk of recurrence (node-positive or hormone receptor-negative disease) APHINITY
    Breast Cancer
    		 Early Breast Cancer HER2+ APHINITY

    C

    PRELIMINARY SCORE

    • iDFS

    ADJUSTMENTS

    SCORE

    • F1

      C
    Neratinib - Placebo Extended adjuvant treatment of patients with early-stage hormone receptor-positive HER2-positive breast cancer who completed adjuvant trastuzumab-based therapy ExteNET
    Breast Cancer
    		 Early Breast Cancer HR+ HER2+ ExteNET

    NEB

    PRELIMINARY SCORE

    • NEB

    ADJUSTMENTS

    SCORE

    • F1
      NEB
    Lenvatinib - Placebo As monotherapy for the treatment of adult patients with progressive, locally advanced or metastatic, differentiated (papillary/follicular/Hürthle cell) thyroid carcinoma (DTC), refractory to radioactive iodine (RAI) SELECT
    Endocrine Tumours
    		 Thyroid cancer - differentiated MKI targeting VEGFR1, VEGFR2 and VEGFR3 SELECT

    2

    PRELIMINARY SCORE

    • PFS

    ADJUSTMENTS

    SCORE

    • F2b
      2
    Sorafenib - Placebo Treatment of patients with progressive, locally advanced or metastatic, differentiated (papillary/follicular/Hürthle cell) thyroid carcinoma, refractory to radioactive iodine DECISION
    Endocrine Tumours
    		 Thyroid cancer - differentiated MKI targeting VEGFR, PDGFR and Raf family kinases DECISION

    2

    PRELIMINARY SCORE

    • PFS

    ADJUSTMENTS

    SCORE

    • F2b
      2
    Vandetanib - Placebo Treatment of aggressive and symptomatic MTC in patients with unresectable locally acvanced or metastatic disease in adults, children and adolescents aged 5 years and older. For patients in whom re-arranged-during-transfection(RET) mutation is not known or is negative, a possible lower benefit should be taken into account before individual treatment decision ZETA
    Endocrine Tumours
    		 Thyroid Cancer - medullary MKI targeting RET, VEGFR2 and EGFR ZETA

    2

    PRELIMINARY SCORE

    • PFS

    ADJUSTMENTS

    SCORE

    • F2b
      2
    Cabazitaxel Prednisone or prednisolone Abiraterone or enzalutamide (alternative to previously used) In combination with prednisone or prednisolone is indicated for the treatment of patients with hormone-refractory metastatic prostate cancer previously treated with a docetaxel-containing regimen CARD
    Genitourinary Cancers
    		 Prostate cancer - CARD

    3

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a
      3
    Ramucirumab - Placebo As monotherapy for the treatment of adult patients with advanced or unresectable HCC who have serum AFP of ≥ 400 ng/ml and who have been previously treated with sorafenib REACH-2
    Gastrointestinal Cancers
    		 Hepatobiliary Cancers - Hepatocellular Carcinoma - REACH-2

    1

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a
      1
    Dacomitinib - Gefitinib As monotherapy for the first-line treatment of adult patients with locally advanced or metastatic NSCLC with EGFR activating mutations. ARCHER 1050
    Thoracic Malignancies
    		 Non-small-cell Lung Cancer EGFR+ ARCHER 1050

    3

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a
      3
    Lorlatinib - Single arm As monotherapy is indicated for the treatment of adult patients with ALK+ advanced NSCLC whose disease has progressed after alectinib or ceritinib as the first ALK TKI therapy; or crizotinib and at least one other ALK TKI B7461001
    Thoracic Malignancies
    		 Non-small-cell Lung Cancer ALK+ B7461001

    4

    PRELIMINARY SCORE

    • ORR

    ADJUSTMENTS

    SCORE

    • F3
      4
    Larotrectinib - Single arm (Phase I/II) Adult and paediatric patients with solid tumours that display an NTRK gene fusion, who have disease that is locally advanced, metastatic or where surgical resection is likely to result in severe morbidity, and who have no satisfactory treatment options SCOUT and NAVIGATE
    Tumour agnostic
    		 - NTRK gene fusion SCOUT and NAVIGATE

    3

    PRELIMINARY SCORE

    • ORR

    ADJUSTMENTS

    SCORE

    • F3
      3
    Olaparib - Placebo Maintenance treatment of adult patients with advanced (FIGO stages III and IV) BRCA1/2-mutated (germline and/or somatic) high-grade epithelial ovarian, fallopian tube or primary peritoneal cancer who are in response (complete or partial) following completion of first-line platinum-based chemotherapy SOLO-1
    Gynaecological Malignancies
    		 High-grade epithelial ovarian, fallopian tube or primary peritoneal cancer BRCA-mut SOLO-1

    4

    PRELIMINARY SCORE

    • PFS

    ADJUSTMENTS

    SCORE

    • F2b
      4
    Olaparib - Placebo Maintenance therapy in patients with platinum-sensitive relapsed high-grade epithelial ovarian, fallopian tube or primary peritoneal cancer who are in response (complete or partial) to platinum-based ChT SOLO-2
    Gynaecological Malignancies
    		 Ovarian, fallopian tubes and peritoneum cancer BRCA-mut SOLO-2

    2

    PRELIMINARY SCORE

    • PFS

    ADJUSTMENTS

    SCORE

    • F2b
      2
    Trifluridine/Tipiracil (TAS-102) - Placebo Metastatic gastric cancer including adenocarcinoma of the gastroesophageal junction, in patients who have been previously treated with ≥2 prior systemic treatment regimens for advanced disease TAGS
    Gastrointestinal Cancers
    		 Gastric or gastroesophageal junction adenocarcinoma - TAGS

    3

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a
      3
    Pembrolizumab Axitinib Sunitinib First-line treatment of advanced RCC in adults KEYNOTE-426
    Genitourinary Cancers
    		 Renal cell cancer - KEYNOTE-426

    4

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a
      4
    Avelumab Axitinib Sunitinib First-line treatment of adult patients with advanced RCC JAVELIN Renal 101
    Genitourinary Cancers
    		 Renal cell cancer - JAVELIN Renal 101

    3

    PRELIMINARY SCORE

    • PFS

    ADJUSTMENTS

    SCORE

    • F2b
      3
    Lanreotide - Placebo Grade 1 and a subset of grade 2 (Ki67 index up to 10%) GEP-NETs of midgut, pancreatic or unknown origin where hindgut sites of origin have been excluded, in adult patients with unresectable locally advanced or metastatic disease CLARINET
    Endocrine Tumours
    		 Neuroendocrine Tumour - Entero-pancreatic Ki67 index up t o 10% CLARINET

    3

    PRELIMINARY SCORE

    • PFS

    ADJUSTMENTS

    SCORE

    • F2b
      3
    Everolimus Best supportive care Placebo Unresectable or metastatic, well- or moderately-differentiated neuroendocrine tumours of pancreatic origin in adults with progressive disease RADIANT 3
    Endocrine Tumours
    		 Neuroendocrine Tumour - Pancreatic - RADIANT 3

    3

    PRELIMINARY SCORE

    • PFS

    ADJUSTMENTS

    SCORE

    • F2b
      3
    Octreotide - Placebo Treatment of patients with advanced neuroendocrine tumours of the midgut or of unknown primary origin where non-midgut sites of origin have been excluded PROMID
    Endocrine Tumours
    		 Neuroendocrine Tumour - Midgut - PROMID

    3

    PRELIMINARY SCORE

    • PFS

    ADJUSTMENTS

    SCORE

    • F2b
      3
    Sunitinib - Placebo Treatment of unresectable or metastatic, well differentiated pancreatic neuroendocrine tumours with disease progression in adults
    Endocrine Tumours
    		 Neuroendocrine Tumour - Pancreatic - -

    3

    PRELIMINARY SCORE

    • PFS

    ADJUSTMENTS

    SCORE

    • F2b
      3
    177Lu-DOTATATE Best supportive care + octreotide Octreotide Unresectable or metastatic, progressive, well-differentiated (Grade 1 and Grade 2), somatostatin receptor positive-GEP-NETs in adults NETTER-1
    Endocrine Tumours
    		 Neuroendocrine Tumour - Midgut - NETTER-1

    4

    PRELIMINARY SCORE

    • PFS

    ADJUSTMENTS

    SCORE

    • F2b
      4
    Brigatinib - Single arm Monotherapy for the treatment of adult patients with anaplastic lymphoma kinase ALK positive advanced NSCLC previously treated with crizotinib ALTA
    Thoracic Malignancies
    		 Non-small-cell Lung Cancer ALK+ ALTA

    4

    PRELIMINARY SCORE

    • ORR

    ADJUSTMENTS

    SCORE

    • F3
      4
    Pembrolizumab Carboplatin + either paclitaxel or nab-paclitaxel Placebo + carboplatin + either paclitaxel or nab-paclitaxel First-line metastatic squamous non-small cell lung cancer KEYNOTE-407
    Thoracic Malignancies
    		 Non-small-cell Lung Cancer - KEYNOTE-407

    A

    4

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a/F1
      4

      A
    Atezolizumab Bevacizumab, paclitaxel and carboplatin Bevacizumab, paclitaxel and carboplatin In combination with bevacizumab, paclitaxel and carboplatin, is indicated for the first-line treatment of adult patients with metastatic non-squamous non small cell lung cancer (NSCLC) IMpower150
    Thoracic Malignancies
    		 Non-small-cell Lung Cancer - IMpower150

    3

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a
      3
    Atezolizumab Bevacizumab, paclitaxel and carboplatin Bevacizumab, paclitaxel and carboplatin In patients with EGFR mutant or ALK-positive NSCLC, atezolizumab, in combination with bevacizumab, paclitaxel and carboplatin, is indicated only after failure of appropriate targeted therapies IMpower150
    Thoracic Malignancies
    		 Non-small-cell Lung Cancer EGFR+ or ALK-positive IMpower150

    3

    PRELIMINARY SCORE

    • PFS

    ADJUSTMENTS

    SCORE

    • F2b
      3
    Atezolizumab Carboplatin plus nab-paclitaxel Carboplatin plus nab-paclitaxel In combination with nab paclitaxel and carboplatin, is indicated for the first line treatment of adult patients with metastatic non-squamous NSCLC who do not have EGFR mutant or ALK positive NSCLC IMpower130
    Thoracic Malignancies
    		 Non-small-cell Lung Cancer - IMpower130

    3

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a
      3
    Ribociclib Endocrine therapy Placebo + endocrine therapy Treatment of women with HR+, HER2 negative locally advanced or metastatic breast cancer in women who have received prior endocrine therapy.. In pre‑ or perimenopausal women, the endocrine therapy should be combined with a luteinising hormone‑releasing hormone (LHRH) agonist. MONALEESA-7
    Breast Cancer
    		 Breast Cancer HR+ HER2- MONALEESA-7

    5

    PRELIMINARY SCORE

    • OS

    ADJUSTMENTS

    SCORE

    • F2a
      5

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