Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

A
ESMO-MCBS v1.1
Scorecard version: 1

Indication details

Tumour Type
Melanoma
Tumour Sub-type
Cutaneous Melanoma
Tumour stage
Adjuvant
Control Arm
Placebo
Treatment Setting
Adjuvant treatment of adults and adolescents aged 12 years and older with stage IIB, IIC or III melanoma and who have undergone complete resection
Trial Name
KEYNOTE-716

Primary Outcome(s)

Primary Outcome(s)
RFS
Evaluated Outcome
RFS
Form(s)
Form 1

Outcome Data

RFS Control
77% at 18 months
RFS Gain
9.0%
RFS HR
0.61 (0.45-0.82)
QoL Comment
QoL was not a prespecified endpoint

Final Score (after adjustments)

Final curative score
A
Comment
EMA (CHMP) May 2022 EC decision July 2022
FDA approval December 2021

Issue date
30.05.2022
Release date
30.05.2022

ChT; chemotherapy; DFS, disease-free survival; DoR, duration of response; EFS, event-free survival; FFS, failure-free survival; HR, hazard ratio; HRD, homologus recombination deficiency; HRP, homologous recombination proficient; iDFS, invasive disease-free survival; ITT, intention to treat; MFS, metastasis-free survival; NS, not significant; ORR, overall response rate; OS, overall survival; pCR, pathologic complete response.remission; PE, point estimate; PFS, progression-free survival; QoL, quality of life; RFS, relapse-free survival; RR, response rate; rPFS, radiographic progression-free survival; SD, stable disease; SSA, somatostatin analogue; SSTR, somatostatin receptor; TKI, tyrosine kinase inhibitor, TTP, time to progression; WT, wild type

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.