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The ESMO-MCBS consists of 5 evaluation forms.

Choosing which form to use depends on the information available in the peer reviewed publication of the clinical trial that led to the licensed indication of the treatment you are interested in. The type of study will dictate which evaluation form to use. If you wish to learn more about the evaluation process, check the ESMO-MCBS online tutorials.

The highest grade of the ESMO-MCBS is A in the curative setting and this is restricted to new curative treatments with a grade B also to be considered to trigger rapid reimbursement. For non-curative indications 5 is the highest possible grade with 4 also to be considered to trigger rapid consideration for reimbursement.


Quality of Life Checklist To evaluate ESMO-MCBS score adjustments based on quality of life

ESMO-MCBS V1.1 – Evaluation Forms

Evaluation form 1 For new approaches to adjuvant therapy or new potentially curative therapies


Evaluation form 2a - For therapies that are not likely to be curative with primary endpoint of OS with separate sheets for:


 Evaluation form 2b - For therapies that are not likely to be curative with primary endpoint PFS with separate sheets for:

Evaluation form 2c For therapies that are not likely to be curative with primary endpoint other than OS or PFS or equivalent (non-inferiority) studies


Evaluation form 3 For single-arm studies in “orphan diseases” and for diseases with “high unmet need” when primary outcome is PFS or ORR.

For more information on how to use the evaluation forms check out the instructions or the online tutorial.

Read the pivotal articles of the ESMO-MCBS:

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