S. Pignata reviews results of studies on gynecological malignancies presented at ASCO 2015. He provides expert insights on the benefit of trebaninib in patients with ascites in the TRINOVA-1 study, biomarker-driven PENELOPE study of pertuzumab in pt-resistant ovarian cancer, toxicity data in the PORTEC-3 study, and risk of uterine cancer following salpingo-oophorectomy in women with BRCA mut.