KEYNOTE-598 Rules Out Pembrolizumab–Ipilimumab For PD–L1-Positive Metastatic NSCLC
Metastatic non-small-cell lung cancer patients with a PD-L1 TPS score of 50% or higher do not benefit from use of ipilimumab alongside first-line pembrolizumab
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Metastatic non-small-cell lung cancer patients with a PD-L1 TPS score of 50% or higher do not benefit from use of ipilimumab alongside first-line pembrolizumab
For advanced non-small-cell lung cancer patients, overall survival is improved when first-line nivolumab plus ipilimumab is supplemented with two cycles of chemotherapy
From the World Conference on Lung Cancer 2022:
Lead-in sotorasib monotherapy followed by the addition of pembrolizumab has shown early promise for the treatment of advanced KRAS G12C-mutated NSCLC
From ASCO 2022 Annual Meeting:
Preliminary findings indicate that patients with tumours harbouring NRG1 fusions may benefit from treatment with zenocutuzumab or seribantumab
From ASCO 2022 Annual Meeting:
Amivantamab shows activity in NSCLC patients with a primary MET exon 14 skipping mutation and when used in combination with lazertinib for those with EGFR mutations who have progressed after osimertinib and chemotherapy
From ESMO Breast Cancer 2022:
For patients with hormone receptor-positive, HER2-negative advanced breast cancer, the addition of ribociclib to fulvestrant continues to significantly improves overall survival after more than 70 months
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