On 21 February 21 2017, his Excellency the President Lieutenant General Dr Seretse Khama Ian Khama of the Republic of Botswana, the Honorable Minister Dorcas Makgato of the Ministry of Health and Wellness, the Bristol-Myers Squibb Foundation, Texas Children’s Cancer and Hematology Centers and Baylor College of Medicine International Pediatric AIDS Initiative at Texas Children’s Hospital (BIPAI) through public-private partnerships with the governments of Botswana, Uganda and Malawi, announced a 100 million USD initiative to create an innovative paediatric haematology-oncology treatment network in southern and east Africa. The comprehensive initiative called Global HOPE (Hematology-Oncology Pediatric Excellence) will build long-term capacity to treat and dramatically improve the prognosis of thousands of children with cancer and blood disorders in southern and eastern Africa.
In the United States, 80% of children with cancer survive. In sub-Saharan Africa, the overwhelming majority of paediatric patients do not survive. The mortality rate is estimated to be as high as 90%, meaning that thousands of children die from cancer across Africa each year. This is in large part due to an inadequate healthcare infrastructure and a significant lack of expert physicians and other healthcare workers trained to treat children with cancer. The most common types of childhood cancers are blood cancers, including leukaemia and lymphoma.
Global HOPE will partner with local Governments and Ministries of Health to build medical capacity to diagnose and treat paediatric blood disorders and cancer in Botswana, Malawi and Uganda. The initiative will also create significant clinical, educational and research capabilities. Doctors, nurses and ancillary professionals will be recruited from around the world to provide training to local healthcare professionals and to begin treating children with blood disorders and cancer immediately.
The Bristol-Myers Squibb Foundation is committing 50 million USD over five years to fund the training of healthcare providers as well as clinical infrastructure and operations. BIPAI will raise an additional 50 million USD for the initiative.
As public-private partnerships, the various governments will each play an important role in developing the paediatric haematology-oncology network, assisting with the training, technical assistance, logistics and resources to support Global HOPE.
The Global HOPE initiative will train an estimated 4,800 healthcare professionals from Botswana, Uganda, Malawi and other African countries, including doctors and nurses specialising in paediatric haematology-oncology and social workers. The programme estimates that over 5,000 children will receive care in the first five years.
“With only five pediatric oncologists currently in the countries of Botswana, Malawi and Uganda combined, there are simply not enough expert doctors to treat all the children diagnosed with blood disorders and cancer. We believe in these countries there are more than 11,000 new cases annually of pediatric cancer and 40,000 new cases of serious, life-threatening blood disorders such as sickle cell disease and hemophilia. Because of these staggering numbers, more healthcare providers with special expertise are urgently needed,” said Dr David G. Poplack, director of Texas Children’s Cancer and Hematology Centers and Professor of Pediatric Oncology at Baylor College of Medicine. “Global HOPE will help build capacity in the region to diagnose and care for children with blood disorders and cancer, offering the potential for transformational change in survivorship for these children.”
The Global HOPE initiative will be modelled on the work of the Bristol-Myers Squibb Foundation, BIPAI and the Governments of Botswana, Uganda and Malawi, which created the largest paediatric HIV treatment network in the world, leveraging existing experience, infrastructure, and public/private partnerships created through the initiative. Since 2003, the Bristol-Myers Squibb Foundation and BIPAI have trained 52,000 healthcare professionals and currently provide care for nearly 300,000 children with HIV and their families in sub-Saharan Africa, lowering the mortality rate for these children to 1.2%.
“The success we’ve had in radically changing the course of pediatric HIV/AIDS in sub-Saharan Africa is due in large part to the tremendous support provided by the country governments, healthcare providers on the ground and donors who have made our work possible,” said Dr Mark W. Kline, president and founder of BIPAI, physician-in-chief of Texas Children’s Hospital and chair of the Department of Pediatrics at Baylor College of Medicine. “We look forward to helping patients and their families by embarking on this unchartered area of cancer care in Africa. Working with our partners, we aim to build a self-sustaining infrastructure that changes the tide of these childhood diseases in sub-Saharan Africa.”