ESMO-Magnitude of Clinical Benefit Scale: Evaluation Forms version 1.1

The ESMO-Magnitude of Clinical Benefit Scale uses a rational, structured and consistent approach to derive a relative ranking of the magnitude of clinically meaningful benefit that can be expected from a new anti-cancer treatment

There are several evaluation forms, which can be downloaded below:

Evaluation form 1

For new approaches to adjuvant therapy or new potentially curative therapies

Evaluation form 2a

For therapies that are not likely to be curative with primary endpoint of OS with separate sheets for:

  • IF median OS with the standard treatment is <12 months
  • IF median OS with the standard treatment is >12 months, <24 months
  • IF median OS with the standard treatment is >24 months

Evaluation form 2b

For therapies that are not likely to be curative with primary endpoint PFS with separate sheets for:

  • IF median PFS with standard treatment is <6 months
  • IF median PFS with standard treatment is >6 months

Evaluation form 2c

For therapies that are not likely to be curative with primary endpoint other than OS or PFS or equivalent (non-inferiority) studies

Evaluation form 3

For single-arm studies in “orphan diseases” and for diseases with “high unmet need” when primary outcome is PFS or ORR.

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