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ESMO-MCBS Scorecards

ESMO MCBS  1000x150

The ESMO-MCBS Scorecards provides a centralised location of cancer medicines that have been scored and published by ESMO.

It includes all cancer medicines approved by the European Medicines Agency (from January 2016) and the US Food and Drug Administration (from January 2020).

ESMO-MCBS Scores
Number of studies
Non-curative setting
5 17
4 95
3 127
2 35
1 19
Curative setting
A 39
C 2
ESMO-MCBS Scores by tumour type
Non-curative setting
Breast Cancer 29
Central Nervous System Malignancies 0
Endocrine Tumours 19
Gastrointestinal Cancers 53
Genitourinary Cancers 51
Gynaecological Malignancies 30
Head and neck cancer 6
Refractory NTRK fusion–positive cancers 2
Sarcoma 10
Skin Cancers 24
TMB-H solid tumours 1
Thoracic Malignancies 67
dMMR/MSI-H solid tumours 1
Curative setting
Breast Cancer 8
Central Nervous System Malignancies 1
Endocrine Tumours 0
Gastrointestinal Cancers 15
Genitourinary Cancers 3
Gynaecological Malignancies 0
Head and neck cancer 0
Refractory NTRK fusion–positive cancers 0
Sarcoma 2
Skin Cancers 9
TMB-H solid tumours 0
Thoracic Malignancies 3
dMMR/MSI-H solid tumours 0

The ESMO-MCBS Scorecards

The ESMO-MCBS Scorecards allows you to filter either by Agent, Tumour or Score giving priority to different criteria such as Agent and Tumour Type and Tumour sub-type and Tumour sub-group in the Curative or Non-curative setting. This content will be updated regularly and communicated to ESMO Members.

Evaluation form 1 For new approaches to adjuvant therapy or new potentially curative therapies
Evaluation form 2a For therapies that are not likely to be curative with primary endpoint of OS with separate sheets for:
Evaluation form 2b For therapies that are not likely to be curative with primary endpoint PFS with separate sheets for:
Evaluation form 2c  For therapies that are not likely to be curative with primary endpoint other than OS or PFS or equivalent (non-inferiority) studies
Evaluation form 3  For single-arm studies in “orphan diseases” and for diseases with “high unmet need” when primary outcome is PFS or ORR.

My watchlist

    Tested Agent(s) Combined Agent(s) Control Arm Treatment Setting Tumour Type Tumour Sub-type Tumour Sub-group Trial Name Ref. Score Scorecard Scorecard
    Trastuzumab emtansine (T-DM1) - Trastuzumab Adjuvant treatment of patients with HER2-positive early breast cancer who have residual invasive disease in the breast and/or lymph nodes after neoadjuvant taxane-based and HER2-targeted therapy Breast Cancer Early Breast Cancer HER2+ KATHERINE
    A

    ADJUSTMENTS

    FINAL SCORE

    • F1
      1
    Trastuzumab deruxtecan ADT (androgen deprivation therapy) Trastuzumab emtansine (T-DM1) For adult patients with unresectable or metastatic HER2-positive breast cancer who have received a prior anti-HER2-based regimen either in the metastatic setting, or in the neoadjuvant or adjuvant setting and have developed disease recurrence during or within 6 months of completing therapy Breast Cancer Breast Cancer HER2+ DESTINY-Breast03
    3

    PRELIMINARY SCORE

    • OS
      6

    ADJUSTMENTS

    FINAL SCORE

    • F1
      3
    Trastuzumab - Chemotherapy Patients with HER2-positive early breast cancer following surgery, ChT (neoadjuvant or adjuvant) and RT (if applicable) Breast Cancer Early Breast Cancer HER2+ HERA
    A

    ADJUSTMENTS

    FINAL SCORE

    • F1
      1
    Pertuzumab Trastuzumab + docetaxel Trastuzumab + docetaxel (Randomised phase II study) Neo-adjuvant HER2 overexpressed invasive ductal breast Breast Cancer Early Breast Cancer HER2+ NeoSphere
    C

    ADJUSTMENTS

    FINAL SCORE

    • F1
      3
    T-DM1 - Lapatinib + capecitabine HER2-positive, unresectable locally advanced or metastatic breast cancer who previously received trastuzumab and a taxane (extensive crossover) Breast Cancer Breast Cancer HER2+ EMILIA
    4

    PRELIMINARY SCORE

    • OS
      6

    ADJUSTMENTS

    FINAL SCORE

    • F1
      2
    Pertuzumab Trastuzumab + docetaxel Trastuzumab + docetaxel + placebo HER2-positive locally recurrent unresectable or metastatic breast cancer with no prior anti-HER2 therapy or ChT for metastatic disease Breast Cancer Breast Cancer HER2+ CLEOPATRA
    4

    PRELIMINARY SCORE

    • OS
      5

    ADJUSTMENTS

    FINAL SCORE

    • F1
      2
    Lapatinib Trastuzumab Lapatinib HER2-positive, hormone receptor-negative metastatic breast cancer after progression on prior trastuzumab + ChT regimen(s) Breast Cancer Breast Cancer HER2+ HR- EGF104900
    4

    PRELIMINARY SCORE

    • OS
      5

    ADJUSTMENTS

    FINAL SCORE

    • F1
      2
    Palbociclib Fulvestrant Fulvestrant + placebo Hormone receptor-positive, HER2-negative locally advanced or metastatic breast cancer previously treated with endocrine therapy Breast Cancer Breast Cancer HR+ HER2- PALOMA-3
    4

    PRELIMINARY SCORE

    • OS
      6

    ADJUSTMENTS

    FINAL SCORE

    • F1
      2
    Palbociclib Letrozole Letrozole + placebo First-line postmenopausal, ER-positive, HER2-negative locally advanced metastatic breast cancer Breast Cancer Breast Cancer HR+ HER2- PALOMA-2
    3

    PRELIMINARY SCORE

    • OS
      6

    ADJUSTMENTS

    FINAL SCORE

    • F1
      3
    Palbociclib Letrozole Letrozole (Randomised phase II study) 1st line metastatic HR+ HER2- Breast Cancer Breast Cancer HR+ HER2- PALOMA-1/TRIO-18
    3

    PRELIMINARY SCORE

    • OS
      6

    ADJUSTMENTS

    FINAL SCORE

    • F1
      3

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