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ESMO-MCBS Scorecards

ESMO MCBS  1000x150

The ESMO-MCBS Scorecards provides a centralised location of cancer medicines that have been scored and published by ESMO.

It includes all cancer medicines approved by the European Medicines Agency (from January 2016) and the US Food and Drug Administration (from January 2020).

ESMO-MCBS Scores
Number of studies
Non-curative setting
5 17
4 95
3 127
2 35
1 19
Curative setting
A 39
C 2
ESMO-MCBS Scores by tumour type
Non-curative setting
Breast Cancer 29
Central Nervous System Malignancies 0
Endocrine Tumours 19
Gastrointestinal Cancers 53
Genitourinary Cancers 51
Gynaecological Malignancies 30
Head and neck cancer 6
Refractory NTRK fusion–positive cancers 2
Sarcoma 10
Skin Cancers 24
TMB-H solid tumours 1
Thoracic Malignancies 67
dMMR/MSI-H solid tumours 1
Curative setting
Breast Cancer 8
Central Nervous System Malignancies 1
Endocrine Tumours 0
Gastrointestinal Cancers 15
Genitourinary Cancers 3
Gynaecological Malignancies 0
Head and neck cancer 0
Refractory NTRK fusion–positive cancers 0
Sarcoma 2
Skin Cancers 9
TMB-H solid tumours 0
Thoracic Malignancies 3
dMMR/MSI-H solid tumours 0

The ESMO-MCBS Scorecards

The ESMO-MCBS Scorecards allows you to filter either by Agent, Tumour or Score giving priority to different criteria such as Agent and Tumour Type and Tumour sub-type and Tumour sub-group in the Curative or Non-curative setting. This content will be updated regularly and communicated to ESMO Members.

Evaluation form 1 For new approaches to adjuvant therapy or new potentially curative therapies
Evaluation form 2a For therapies that are not likely to be curative with primary endpoint of OS with separate sheets for:
Evaluation form 2b For therapies that are not likely to be curative with primary endpoint PFS with separate sheets for:
Evaluation form 2c  For therapies that are not likely to be curative with primary endpoint other than OS or PFS or equivalent (non-inferiority) studies
Evaluation form 3  For single-arm studies in “orphan diseases” and for diseases with “high unmet need” when primary outcome is PFS or ORR.

My watchlist

    Tested Agent(s) Combined Agent(s) Control Arm Treatment Setting Tumour Type Tumour Sub-type Tumour Sub-group Trial Name Ref. Score Scorecard Scorecard
    177Lu-DOTATATE Best supportive care + octreotide Octreotide Progressive midgut neuroendocrine tumour on SSA, functional or non-functional; grade 1 or 2, SSTR positive  Endocrine Tumours Neuroendocrine Tumour - Midgut - NETTER-1
    4

    PRELIMINARY SCORE

    • OS
      6

    ADJUSTMENTS

    FINAL SCORE

    • F1
      2
    Pembrolizumab Carboplatin and either paclitaxel or nab-paclitaxel Carboplatin and either paclitaxel or nab-paclitaxel First line metastatic squamous non-small cell lung cancer Thoracic Malignancies Non-small-cell Lung Cancer - KEYNOTE-407
    4

    PRELIMINARY SCORE

    • OS
      5

    ADJUSTMENTS

    FINAL SCORE

    • F1
      2
    Abemaciclib Fulvestrant Fulvestrant + placebo Second-line locally advanced or metastatic breast cancer in postmenopausal, hormone receptor-positive, HER2-negative Breast Cancer Breast Cancer HR+ HER2- MONARCH 2
    4

    PRELIMINARY SCORE

    • OS
      5

    ADJUSTMENTS

    FINAL SCORE

    • F1
      2
    Ribociclib Fulvestrant Placebo + fulvestrant First- or second-line postmenopausal, hormone receptor-positive, HER2-negative advanced breast cancer Breast Cancer Breast Cancer HR+ HER2- MONALEESA-3
    4

    PRELIMINARY SCORE

    • OS
      5

    ADJUSTMENTS

    FINAL SCORE

    • F1
      2
    Talazoparib - Standard chemotherapy Post anathacycline and taxane Breast Cancer Breast Cancer HER2- g-BrCa+ve EMBRACA
    4

    PRELIMINARY SCORE

    • OS
      6

    ADJUSTMENTS

    FINAL SCORE

    • F1
      2
    Olaparib - Standard chemotherapy <2 previous chemotherapy regimens Breast Cancer Breast Cancer HER2- g-BrCa+ve OlympiAD
    4

    PRELIMINARY SCORE

    • OS
      6

    ADJUSTMENTS

    FINAL SCORE

    • F1
      2
    Tucatinib Trastuzumab + capecitabine Placebo, trastuzumab + capecitabine HER2-positive locally advanced or metastatic breast cancer after at least 2 prior anti-HER2 treatment regimes Breast Cancer Breast Cancer HER2+ HER2CLIMB
    4

    PRELIMINARY SCORE

    • OS
      5

    ADJUSTMENTS

    FINAL SCORE

    • F1
      2
    Binimetinib Encorafenib Vemurafenib Advanced unresectable or metastatic melanoma with BRAF V600 Skin Cancers Melanoma BRAF V600 COLUMBUS
    4

    PRELIMINARY SCORE

    • OS
      5

    ADJUSTMENTS

    FINAL SCORE

    • F1
      2
    Durvalumab - Placebo Treatment of locally advanced, unresectable NSCLC in adults whose tumours express PD-L1 on ≥1% of tumour cells and whose disease has not progressed following platinum-based CRT Thoracic Malignancies Non-small-cell Lung Cancer PD-L1 PACIFIC
    4

    PRELIMINARY SCORE

    • OS
      5

    ADJUSTMENTS

    FINAL SCORE

    • F1
      2
    Abiraterone Prednisone + ADT (androgen deprivation therapy) ADT + placebo Treatment of newly diagnosed high risk mHSPC in adult men in combination with ADT Genitourinary Cancers Prostate cancer - LATITUDE
    4

    PRELIMINARY SCORE

    • OS
      5

    ADJUSTMENTS

    FINAL SCORE

    • F1
      2

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