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ESMO-MCBS Scorecards

ESMO MCBS  1000x150

The ESMO-MCBS Scorecards provides a centralised location of cancer medicines that have been scored and published by ESMO.

It includes all cancer medicines approved by the European Medicines Agency (from January 2016) and the US Food and Drug Administration (from January 2020).

ESMO-MCBS Scores
Number of studies
Non-curative setting
5 17
4 95
3 125
2 34
1 19
Curative setting
A 38
C 2
ESMO-MCBS Scores by tumour type
Non-curative setting
Breast Cancer 28
Central Nervous System Malignancies 0
Endocrine Tumours 19
Gastrointestinal Cancers 53
Genitourinary Cancers 51
Gynaecological Malignancies 30
Head and neck cancer 6
Refractory NTRK fusion–positive cancers 2
Sarcoma 10
Skin Cancers 24
TMB-H solid tumours 1
Thoracic Malignancies 65
dMMR/MSI-H solid tumours 1
Curative setting
Breast Cancer 8
Central Nervous System Malignancies 1
Endocrine Tumours 0
Gastrointestinal Cancers 15
Genitourinary Cancers 4
Gynaecological Malignancies 0
Head and neck cancer 0
Refractory NTRK fusion–positive cancers 0
Sarcoma 2
Skin Cancers 8
TMB-H solid tumours 0
Thoracic Malignancies 2
dMMR/MSI-H solid tumours 0

The ESMO-MCBS Scorecards

The ESMO-MCBS Scorecards allows you to filter either by Agent, Tumour or Score giving priority to different criteria such as Agent and Tumour Type and Tumour sub-type and Tumour sub-group in the Curative or Non-curative setting. This content will be updated regularly and communicated to ESMO Members.

Evaluation form 1 For new approaches to adjuvant therapy or new potentially curative therapies
Evaluation form 2a For therapies that are not likely to be curative with primary endpoint of OS with separate sheets for:
Evaluation form 2b For therapies that are not likely to be curative with primary endpoint PFS with separate sheets for:
Evaluation form 2c  For therapies that are not likely to be curative with primary endpoint other than OS or PFS or equivalent (non-inferiority) studies
Evaluation form 3  For single-arm studies in “orphan diseases” and for diseases with “high unmet need” when primary outcome is PFS or ORR.

My watchlist

    Tested Agent(s) Combined Agent(s) Control Arm Treatment Setting Tumour Type Tumour Sub-type Tumour Sub-group Trial Name Ref. Score Scorecard Scorecard
    Erlotinib - Platinum-based chemotherapy doublet 1st line stage III or IV non-squamous, with EGFR mutation Thoracic Malignancies Non-small-cell Lung Cancer EGFR+ EURTAC
    4

    PRELIMINARY SCORE

    • OS
      6

    ADJUSTMENTS

    FINAL SCORE

    • F1
      2
    Gefitinib - Carboplatin + paclitaxel 1st line stage III or IV adenocarcinoma with EGFR mutation Thoracic Malignancies Non-small-cell Lung Cancer EGFR+ IPASS
    4

    PRELIMINARY SCORE

    • OS
      6

    ADJUSTMENTS

    FINAL SCORE

    • F1
      2
    Afatinib - Cisplatin + pemetrexed First-line EGFR TKI-naïve locally advanced or metastatic NSCLC with activating EGFR mutations Thoracic Malignancies Non-small-cell Lung Cancer EGFR+ LUX - Lung 3
    4

    PRELIMINARY SCORE

    • OS
      6

    ADJUSTMENTS

    FINAL SCORE

    • F1
      2
    Afatinib - Cisplatin + pemetrexed 1st line stage III or IV adenocarcinoma with EGFR mutation (Del19/L858R) Thoracic Malignancies Non-small-cell Lung Cancer EGFR+ LUX - Lung 3
    4

    PRELIMINARY SCORE

    • OS
      6

    ADJUSTMENTS

    FINAL SCORE

    • F1
      2
    Osimertinib - Platinum/pemetrexed 2nd line for EGFR mutated NSCLC after TKI with new T790M mutation Thoracic Malignancies Non-small-cell Lung Cancer EGFR+ AURA3
    4

    PRELIMINARY SCORE

    • OS
      6

    ADJUSTMENTS

    FINAL SCORE

    • F1
      2
    Crizotinib - Chemotherapy 2nd line stage III or IV non-squamous, with ALK mutation Thoracic Malignancies Non-small-cell Lung Cancer ALK+ PROFILE 1007
    4

    PRELIMINARY SCORE

    • OS
      6

    ADJUSTMENTS

    FINAL SCORE

    • F1
      2
    Crizotinib - Pemetrexed + cisplatin or carboplatin 1st line stage III or IV non-squamous, with ALK mutation Thoracic Malignancies Non-small-cell Lung Cancer ALK+ PROFILE 1014
    4

    PRELIMINARY SCORE

    • OS
      6

    ADJUSTMENTS

    FINAL SCORE

    • F1
      2
    Pemetrexed - Placebo Stage III or IV disease maintenance after responding to 4 cycles platinum doublet Thoracic Malignancies Non-small-cell Lung Cancer - -
    4

    PRELIMINARY SCORE

    • OS
      5

    ADJUSTMENTS

    FINAL SCORE

    • F1
      2
    Pemetrexed Cisplatin Cisplatin + gemcitabine 1st line stage III or IV (non-squamous) Thoracic Malignancies Non-small-cell Lung Cancer - -
    4

    PRELIMINARY SCORE

    • OS
      5

    ADJUSTMENTS

    FINAL SCORE

    • F1
      2
    Palliative care Chemotherapy Chemotherapy 1st line treatment stage IV NSCLC ECOG<2 Thoracic Malignancies Non-small-cell Lung Cancer - -
    4

    PRELIMINARY SCORE

    • OS
      5

    ADJUSTMENTS

    FINAL SCORE

    • F1
      2

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