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ESMO-MCBS Scorecards

ESMO MCBS  1000x150

The ESMO-MCBS Scorecards provides a centralised location of cancer medicines that have been scored and published by ESMO.

It includes all cancer medicines approved by the European Medicines Agency (from January 2016) and the US Food and Drug Administration (from January 2020).

ESMO-MCBS Scores
Number of studies
Non-curative setting
5 17
4 95
3 125
2 34
1 19
Curative setting
A 38
C 2
ESMO-MCBS Scores by tumour type
Non-curative setting
Breast Cancer 28
Central Nervous System Malignancies 0
Endocrine Tumours 19
Gastrointestinal Cancers 53
Genitourinary Cancers 51
Gynaecological Malignancies 30
Head and neck cancer 6
Refractory NTRK fusion–positive cancers 2
Sarcoma 10
Skin Cancers 24
TMB-H solid tumours 1
Thoracic Malignancies 65
dMMR/MSI-H solid tumours 1
Curative setting
Breast Cancer 8
Central Nervous System Malignancies 1
Endocrine Tumours 0
Gastrointestinal Cancers 15
Genitourinary Cancers 4
Gynaecological Malignancies 0
Head and neck cancer 0
Refractory NTRK fusion–positive cancers 0
Sarcoma 2
Skin Cancers 8
TMB-H solid tumours 0
Thoracic Malignancies 2
dMMR/MSI-H solid tumours 0

The ESMO-MCBS Scorecards

The ESMO-MCBS Scorecards allows you to filter either by Agent, Tumour or Score giving priority to different criteria such as Agent and Tumour Type and Tumour sub-type and Tumour sub-group in the Curative or Non-curative setting. This content will be updated regularly and communicated to ESMO Members.

Evaluation form 1 For new approaches to adjuvant therapy or new potentially curative therapies
Evaluation form 2a For therapies that are not likely to be curative with primary endpoint of OS with separate sheets for:
Evaluation form 2b For therapies that are not likely to be curative with primary endpoint PFS with separate sheets for:
Evaluation form 2c  For therapies that are not likely to be curative with primary endpoint other than OS or PFS or equivalent (non-inferiority) studies
Evaluation form 3  For single-arm studies in “orphan diseases” and for diseases with “high unmet need” when primary outcome is PFS or ORR.

My watchlist

    Tested Agent(s) Combined Agent(s) Control Arm Treatment Setting Tumour Type Tumour Sub-type Tumour Sub-group Trial Name Ref. Score Scorecard Scorecard
    5-FU/LV (5-fluorouracil + leucovorin) - Lomustine (MeCCNU) + vincristine + 5-FU Patients with Dukes' stage B and C colon cancer Gastrointestinal Cancers Colon Cancer - NSABP C-03
    A

    ADJUSTMENTS

    FINAL SCORE

    • F1
      1
    5-FU (fluorouracil) Folinic acid Observation Patients with surgically resected colon cancer in Dukes' stage C Gastrointestinal Cancers Colon Cancer - -
    A

    ADJUSTMENTS

    FINAL SCORE

    • F1
      1
    5-FU/LV (fluorouracil + leucovorin) - Observation High-risk stage II or stage III colon cancer Gastrointestinal Cancers Colon Cancer - NCCTG 874651
    A

    ADJUSTMENTS

    FINAL SCORE

    • F1
      1
    5-FU (fluorouracil) Folinic acid Surgery alone Patients with resectable Dukes B and C (AJCC/UICC Stage II and Stage III) colon carcinoma Gastrointestinal Cancers Colon Cancer - GIVIO-SITAC 01
    A

    ADJUSTMENTS

    FINAL SCORE

    • F1
      1
    5-FU/LV (fluorouracil + leucovorin) or 5-FU/LEV (fluorouracil + levamisole) - Surgery alone (Meta-analysis) Patients with stage II and III colon cancer (ITT and age stratified including >70 years) Gastrointestinal Cancers Colon Cancer - -
    A

    ADJUSTMENTS

    FINAL SCORE

    • F1
      1
    5-FU/LV (fluorouracil + leucovorin) or 5-FU/LEV (fluorouracil + levamisole) - Surgery alone (Pooled-analysis) Patients with stage II and III colon cancer Gastrointestinal Cancers Colon Cancer - -
    A

    ADJUSTMENTS

    FINAL SCORE

    • F1
      1
    5-FU/LV (fluorouracil + leucovorin) or 5-FU/LEV (fluorouracil + levamisole) - Surgery alone (Meta-analysis) Patients with resected stage II and III colon cancer Gastrointestinal Cancers Colon Cancer - -
    A

    ADJUSTMENTS

    FINAL SCORE

    • F1
      1
    5-FU/LV (fluorouracil + leucovorin) or 5-FU/LEV (fluorouracil + levamisole) - Surgery alone (Meta-analysis) Patients with resected stage II and III colon cancer Gastrointestinal Cancers Colon Cancer - -
    A

    ADJUSTMENTS

    FINAL SCORE

    • F1
      1
    5FU/LEV (5-fluorouracil + levamisole) - Levamisole Resected stage III (Dukes stage C) colon cancer Gastrointestinal Cancers Colon Cancer - Intergroup 0035
    A

    ADJUSTMENTS

    FINAL SCORE

    • F1
      1
    Nivolumab - Placebo Adjuvant therapy for adult patients with oesophageal or gastroesophageal junction cancer who have residual pathologic disease following prior neoadjuvant chemoradiotherapy Gastrointestinal Cancers Oesophageal or gastroesophageal carcinoma - CheckMate 577
    A

    ADJUSTMENTS

    FINAL SCORE

    • F1
      1

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