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ESMO-MCBS Scorecards

ESMO MCBS  1000x150

The ESMO-MCBS Scorecards provides a centralised location of cancer medicines that have been scored and published by ESMO.

It includes all cancer medicines approved by the European Medicines Agency (from January 2016) and the US Food and Drug Administration (from January 2020).

ESMO-MCBS Scores
Number of studies
Non-curative setting
5 17
4 95
3 125
2 34
1 19
Curative setting
A 38
C 2
ESMO-MCBS Scores by tumour type
Non-curative setting
Breast Cancer 28
Central Nervous System Malignancies 0
Endocrine Tumours 19
Gastrointestinal Cancers 53
Genitourinary Cancers 51
Gynaecological Malignancies 30
Head and neck cancer 6
Refractory NTRK fusion–positive cancers 2
Sarcoma 10
Skin Cancers 24
TMB-H solid tumours 1
Thoracic Malignancies 65
dMMR/MSI-H solid tumours 1
Curative setting
Breast Cancer 8
Central Nervous System Malignancies 1
Endocrine Tumours 0
Gastrointestinal Cancers 15
Genitourinary Cancers 4
Gynaecological Malignancies 0
Head and neck cancer 0
Refractory NTRK fusion–positive cancers 0
Sarcoma 2
Skin Cancers 8
TMB-H solid tumours 0
Thoracic Malignancies 2
dMMR/MSI-H solid tumours 0

The ESMO-MCBS Scorecards

The ESMO-MCBS Scorecards allows you to filter either by Agent, Tumour or Score giving priority to different criteria such as Agent and Tumour Type and Tumour sub-type and Tumour sub-group in the Curative or Non-curative setting. This content will be updated regularly and communicated to ESMO Members.

Evaluation form 1 For new approaches to adjuvant therapy or new potentially curative therapies
Evaluation form 2a For therapies that are not likely to be curative with primary endpoint of OS with separate sheets for:
Evaluation form 2b For therapies that are not likely to be curative with primary endpoint PFS with separate sheets for:
Evaluation form 2c  For therapies that are not likely to be curative with primary endpoint other than OS or PFS or equivalent (non-inferiority) studies
Evaluation form 3  For single-arm studies in “orphan diseases” and for diseases with “high unmet need” when primary outcome is PFS or ORR.

My watchlist

    Tested Agent(s) Combined Agent(s) Control Arm Treatment Setting Tumour Type Tumour Sub-type Tumour Sub-group Trial Name Ref. Score Scorecard Scorecard
    Trastuzumab emtansine (T-DM1) - Trastuzumab Adjuvant treatment of patients with HER2-positive early breast cancer who have residual invasive disease in the breast and/or lymph nodes after neoadjuvant taxane-based and HER2-targeted therapy Breast Cancer Breast Cancer HER2+ KATHERINE
    A

    ADJUSTMENTS

    FINAL SCORE

    • F1
      1
    Trastuzumab - Chemotherapy Adjuvant or neo-adjuvant HER2 positive tumours Breast Cancer Breast Cancer HER2+ HERA
    A

    ADJUSTMENTS

    FINAL SCORE

    • F1
      1
    Epirubicin, 5-FU, Cisplatin - Surgery Peri-operative resectable gastric or gastroesophageal junction adenocarcinoma Gastrointestinal Cancers Gastric or gastro-oesophageal junction adenocarcinoma - MAGIC
    A

    ADJUSTMENTS

    FINAL SCORE

    • F1
      1
    5-FU, Cisplatin - Surgery Peri-operative resectable gastric or gastroesophageal junction adenocarcinoma Gastrointestinal Cancers Gastric or gastro-oesophageal junction adenocarcinoma - FRE-FNCLCC-94012
    A

    ADJUSTMENTS

    FINAL SCORE

    • F1
      1
    Ipilimumab - Placebo Adjuvant stage III melanoma Skin Cancers Melanoma - EORTC 18071
    A

    ADJUSTMENTS

    FINAL SCORE

    • F1
      1
    Ipilimumab Dacarbazine Dacarbazine + placebo 1st line treatment Skin Cancers Melanoma - CA184-024
    4

    PRELIMINARY SCORE

    • OS
      5

    ADJUSTMENTS

    FINAL SCORE

    • F1
      1
    • F1
      2
    Dinutuximab Cis retinoic acid+GMCSF+IL2 Cis retinoic acid <32 years old with high-risk neuroblastoma after remission and stem cell transplatation Central Nervous System Malignancies Neuro-oncology cancer - Neuroblastoma - -
    A

    ADJUSTMENTS

    FINAL SCORE

    • F1
      1
    FLOT (docetaxel, oxaliplatin, fluorouracil and leucovorin) - Fluorouracil or capecitabine plus cisplatin and epirubicin Peri-operative locally advanced, resectable gastric or gastroesophageal junction adenocarcinoma Gastrointestinal Cancers Gastric or gastro-oesophageal junction adenocarcinoma - FLOT4
    A

    ADJUSTMENTS

    FINAL SCORE

    • F1
      1
    Gemcitabine Capecitabine Gemcitabine Resected pancreatic ductal adenocarcinoma Gastrointestinal Cancers Pancreatic cancer - ESPAC-4
    A

    ADJUSTMENTS

    FINAL SCORE

    • F1
      1
    mFOLFIRINOX - Gemcitabine Resected pancreatic ductal adenocarcinoma Gastrointestinal Cancers Pancreatic cancer - PRODIGE 24/CCTG PA. 6 trial
    A

    ADJUSTMENTS

    FINAL SCORE

    • F1
      1

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