The ESMO-MCBS Scorecards allows you to filter either by Agent, Tumour or Score giving priority to different criteria such as Agent and Tumour Type and Tumour sub-type and Tumour sub-group in the Curative or Non-curative setting. This content will be updated regularly and communicated to ESMO Members.
Locally advanced or metastatic NSCLC with EGFR activating mutationsOPTIMAL, CTONG-0802
Thoracic Malignancies
Non-small-cell Lung Cancer
EGFR+
OPTIMAL, CTONG-0802
4
PRELIMINARY SCORE
PFS
ADJUSTMENTS
FINAL SCORE
F2b
4
Erlotinib
-
Platinum-based chemotherapy doublet
Locally advanced or metastatic NSCLC with EGFR activating mutationsEURTAC
Thoracic Malignancies
Non-small-cell Lung Cancer
EGFR+
EURTAC
4
PRELIMINARY SCORE
PFS
ADJUSTMENTS
FINAL SCORE
F2b
4
Gefitinib
-
Carboplatin + paclitaxel
Treatment of adult patients with locally advanced or metastatic NSCLC with activating mutations of EGFR tyrosine kinase.IPASS
Thoracic Malignancies
Non-small-cell Lung Cancer
EGFR+
IPASS
4
PRELIMINARY SCORE
PFS
ADJUSTMENTS
FINAL SCORE
F2b
4
Afatinib
-
Cisplatin + pemetrexed
As monotherapy for the treatment of EGFR TKI-naïve adult patients with locally advanced or metastatic NSCLC with activating EGFR mutation(s)LUX - Lung 3
Thoracic Malignancies
Non-small-cell Lung Cancer
EGFR+
LUX - Lung 3
4
PRELIMINARY SCORE
PFS
ADJUSTMENTS
FINAL SCORE
F2b
4
Osimertinib
-
Platinum/pemetrexed
As monotherapy for the treatment of adult patients with locally advanced or metastatic EGFR T790M mutation-positive NSCLCAURA3
Thoracic Malignancies
Non-small-cell Lung Cancer
EGFR+
AURA3
4
PRELIMINARY SCORE
PFS
ADJUSTMENTS
FINAL SCORE
F2b
4
Crizotinib
-
Chemotherapy
Treatment of adults with previously treated anaplastic lymphoma kinase (ALK) positive advanced non-small cell lung cancer (NSCLC)PROFILE 1007
Thoracic Malignancies
Non-small-cell Lung Cancer
ALK+
PROFILE 1007
4
PRELIMINARY SCORE
PFS
ADJUSTMENTS
FINAL SCORE
F2b
4
Crizotinib
-
Pemetrexed + cisplatin or carboplatin
First-line treatment of adults with anaplastic lymphoma kinase (ALK)-positive advanced non-small cell lung cancer (NSCLC)PROFILE 1014
Thoracic Malignancies
Non-small-cell Lung Cancer
ALK+
PROFILE 1014
4
PRELIMINARY SCORE
PFS
ADJUSTMENTS
FINAL SCORE
F2b
4
Pemetrexed
-
Placebo
As monotherapy for the maintenance treatment of locally advanced or metastatic NSCLC other than predominantly squamous cell histology in patients whose disease has not progressed immediately following platinum-based chemotherapy
Thoracic Malignancies
Non-small-cell Lung Cancer
-
-
4
PRELIMINARY SCORE
OS
ADJUSTMENTS
FINAL SCORE
F2a
4
Pemetrexed
Cisplatin
Cisplatin + gemcitabine
In combination with cisplatin for the first-line treatment of patients with locally advanced or metastatic NSCLC other than predominantly squamous cell histology
Thoracic Malignancies
Non-small-cell Lung Cancer
-
-
4
PRELIMINARY SCORE
NI
ADJUSTMENTS
FINAL SCORE
F2c
4
Palliative care
Chemotherapy
Chemotherapy
First-line treatment stage IV NSCLC ECOG<2
Thoracic Malignancies
Non-small-cell Lung Cancer
-
-
4
PRELIMINARY SCORE
NI
ADJUSTMENTS
FINAL SCORE
F2c
4
Nivo/Ipi (nivolumab and ipilimumab)
-
Ipilimumab
Ipilimumab in combination with nivolumab is indicated for the treatment of advanced (unresectable or metastatic) melanoma in adults and adolescents 12 years of age and older*CheckMate 067
Skin Cancers
Cutaneous Melanoma
-
CheckMate 067
A
4
PRELIMINARY SCORE
OS
ADJUSTMENTS
FINAL SCORE
F2a/F1
4
A
Nivolumab
-
Ipilimumab
Monotherapy for the treatment of advanced melanoma in adults and adolescents 12 years of age and older*CheckMate 067
Skin Cancers
Cutaneous Melanoma
-
CheckMate 067
A
4
PRELIMINARY SCORE
OS
ADJUSTMENTS
FINAL SCORE
F2a/F1
4
A
Ipilimumab
-
Glycoprotein 100 (GP100)
Second-line treatment in advanced (unresectable or metastatic) melanoma in adults and adolescents 12 years of age and older (pre-immunotherapy era)MDX010-20
Skin Cancers
Cutaneous Melanoma
HLA-A*0201
MDX010-20
4
PRELIMINARY SCORE
OS
ADJUSTMENTS
FINAL SCORE
F2a
4
Vemurafenib
-
Dacarbazine
As monotherapy for the treatment of adult patients with BRAF V600 mutation-positive unresectable or metastatic melanomaBRIM-3
Skin Cancers
Cutaneous Melanoma
BRAF V600E
BRIM-3
4
PRELIMINARY SCORE
OS
ADJUSTMENTS
FINAL SCORE
F2a
4
Vemurafenib
-
Dacarbazine
As monotherapy for the treatment of adult patients with BRAF V600 mutation-positive unresectable or metastatic melanomaBRIM-3
Skin Cancers
Cutaneous Melanoma
BRAF V600K
BRIM-3
4
PRELIMINARY SCORE
OS
ADJUSTMENTS
FINAL SCORE
F2a
4
Trametinib
-
Dacarbazine or paclitaxel
As monotherapy for the treatment of adult patients with unresectable or metastatic melanoma with a BRAF V600 mutationMETRIC
Skin Cancers
Cutaneous Melanoma
BRAF V600
METRIC
4
PRELIMINARY SCORE
PFS
ADJUSTMENTS
FINAL SCORE
F2b
4
Dab/Tram (dabrafenib and trametinib)
-
Dabrafenib
Dabrafenib in combination with trametinib for the treatment of adult patients with unresectable or metastatic melanoma with a BRAF V600 mutationCOMBI-d
Skin Cancers
Cutaneous Melanoma
BRAF V600
COMBI-d
4
PRELIMINARY SCORE
PFS
ADJUSTMENTS
FINAL SCORE
F2b
4
Dabrafenib
-
Dacarbazine
Treatment of adult patients with unresectable or metastatic melanoma with a BRAF V600 mutationBREAK-3
Skin Cancers
Cutaneous Melanoma
BRAF V600E
BREAK-3
4
PRELIMINARY SCORE
PFS
ADJUSTMENTS
FINAL SCORE
F2b
4
Cobimetinib
Vemurafenib
Vemurafenib + placebo
In combination with vemurafenib for the treatment of adult patients with unresectable or metastatic melanoma with a BRAF V600 mutationcoBRIM
Skin Cancers
Cutaneous Melanoma
BRAF V600E
coBRIM
4
PRELIMINARY SCORE
OS
ADJUSTMENTS
FINAL SCORE
F2a
4
Nivolumab
-
Dacarbazine
As monotherapy for the treatment of advanced (unresectable or metastatic) melanoma in adultsCheckMate 066
Skin Cancers
Cutaneous Melanoma
-
CheckMate 066
A
4
PRELIMINARY SCORE
OS
ADJUSTMENTS
FINAL SCORE
F2a/F1
4
A
Ipilimumab
Dacarbazine
Dacarbazine + placebo
Advanced (unresectable or metastatic) melanoma in adults and adolescents 12 years of age and older (Basis of EMA and FDA approval of 1st-line ipilimumab monotherapy)CA184-024
Skin Cancers
Cutaneous Melanoma
-
CA184-024
A
4
PRELIMINARY SCORE
OS
ADJUSTMENTS
FINAL SCORE
F2a/F1
4
A
Radium-223
Best standard of care
Best standard of care + placebo
Treatment of adults with castration-resistant prostate cancer, symptomatic bone metastases and no known visceral metastasesALSYMPCA
Genitourinary Cancers
Prostate cancer
-
ALSYMPCA
4
PRELIMINARY SCORE
OS
ADJUSTMENTS
FINAL SCORE
F2a
4
Abiraterone
Prednisone
Prednisone + placebo
Indicated with prednisone or prednisolone for the treatment of mCRPC in adult men whose disease has progressed on or after a docetaxel-based ChT regimenCOU-AA-301
Genitourinary Cancers
Prostate cancer
-
COU-AA-301
4
PRELIMINARY SCORE
OS
ADJUSTMENTS
FINAL SCORE
F2a
4
Enzalutamide
-
Placebo
Adult men with mCRPC whose disease has progressed on or after docetaxel therapyAFFIRM
Genitourinary Cancers
Prostate cancer
-
AFFIRM
4
PRELIMINARY SCORE
OS
ADJUSTMENTS
FINAL SCORE
F2a
4
Enzalutamide
-
Placebo
Castraction-refractory pre-docetaxel (early termination with crossover)PREVAIL
Genitourinary Cancers
Prostate cancer
-
PREVAIL
4
PRELIMINARY SCORE
PFS
ADJUSTMENTS
FINAL SCORE
F2b
4
Axitinib
-
Sorafenib
Treatment of adult patients with advanced RCC after failure of prior treatment with sunitinib or cytokineAXIS
Genitourinary Cancers
Renal cell cancer
-
AXIS
3
PRELIMINARY SCORE
PFS
ADJUSTMENTS
FINAL SCORE
F2b
3
Pazopanib
-
Sunitinib
First-line treatment of advanced renal-cell carcinoma (RCC) and for patients who have received prior cytokine therapy for advanced disease COMPARZ
Genitourinary Cancers
Renal cell cancer
-
COMPARZ
4
PRELIMINARY SCORE
NI
ADJUSTMENTS
FINAL SCORE
F2c
4
Sunitinib
-
Interferon
Treatment of advanced/metastatic renal cell carcinoma in adults
Genitourinary Cancers
Renal cell cancer
-
-
4
PRELIMINARY SCORE
PFS
ADJUSTMENTS
FINAL SCORE
F2b
4
Lenvatinib
Everolimus
Everolimus
Treatment of adults with advanced renal cell carcinoma in combination with everolimus following one prior vascular endothelial growth factor (VEGF)-targeted therapy
Genitourinary Cancers
Renal cell cancer
-
-
4
PRELIMINARY SCORE
OS
ADJUSTMENTS
FINAL SCORE
F2a
4
Regorafenib
-
Placebo
As monotherapy for the treatment of adult patients with hepatocellular carcinoma (HCC) who have been previously treated with sorafenibRESORCE
Gastrointestinal Cancers
Hepatobiliary Cancers - Hepatocellular Carcinoma
-
RESORCE
4
PRELIMINARY SCORE
OS
ADJUSTMENTS
FINAL SCORE
F2a
4
Watchlist
Tested Agent(s)
Combined Agent(s)
Control Arm
Therapeutic Indication
Tumour Type
Tumour Sub-type
Tumour Sub-group
Trial Name
Ref.
Score
Scorecard
Scorecard
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