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ESMO-Magnitude of Clinical Benefit Scale

ESMO MCBS  1000x150

The searchable portal provides a centralised location of cancer medicines that have been scored and published by ESMO.

The ESMO-MCBS Score Card

The ESMO-MCBS Score Card allows you to filter either by Agent, Tumour or Score giving priority to different criteria such as Agent and Tumour Type and Tumour sub-type and Tumour sub-group in the Curative or Non-curative setting. This content will be updated regularly and communicated to ESMO Members.

Tested Agent(s) Combined Agent(s) Control Arm Treatment Setting Tumour Type Tumour Sub-type Tumour Sub-group Tumour Stage Score Ref. Score card
T-DM1 Lapatinib + capecitabine 2nd line metastatic after trastuzumab failure (extensive crossover) Breast Cancer Breast Cancer HER2+ Metastatic
4
Pertuzumab Trastuzumab + docetaxel Trastuzumab + docetaxel + placebo 1st line metastatic Breast Cancer Breast Cancer HER2+ Metastatic
4
Trastuzumab Lapatinib Lapatinib 3rd line metastatic Breast Cancer Breast Cancer HER2+ Metastatic
4
Palbociclib Fulvestrant Fulvestrant + placebo 2nd line metastatic HR+ HER2- Breast Cancer Breast Cancer HR+ HER2- Metastatic
4
Panitumumab FOLFOX4 FOLFOX4 1st line metastatic colorectal cancer (post hoc KRAS, NRAS BRAF WT) Gastrointestinal Cancers Colon and Rectal Cancer Metastatic
4
Cetuximab FOLFIRI FOLFIRI 1st line metastatic (post hoc KRAS, NRAS WT) Gastrointestinal Cancers Colon and Rectal Cancer RAS-WT Metastatic
4
Cetuximab Best supportive care Refractory metastatic KRAS-WT Gastrointestinal Cancers Colon and Rectal Cancer KRAS-WT Metastatic
4
Bevacizumab Chemotherapy Paclitaxel or topotecan or liposomal doxorubicin Recurrent platinum-resistant ovarian cancer Gynaecological Malignancies Ovarian Cancer Metastatic
4
Nivolumab Chemotherapy Platinum-refractory metastatic H+N squamous cell cancer Head and neck cancer Squamous cell Metastatic
4
Erlotinib Carboplatin gemcitabine 1st line stage III or IV non-squamous, with EGFR mutation Thoracic Malignancies Non-small-cell Lung Cancer EGFR+ Metastatic
4

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