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ESMO-Magnitude of Clinical Benefit Scale

ESMO MCBS  1000x150

The searchable portal provides a centralised location of cancer medicines that have been scored and published by ESMO.

The ESMO-MCBS Score Card

The ESMO-MCBS Score Card allows you to filter either by Agent, Tumour or Score giving priority to different criteria such as Agent and Tumour Type and Tumour sub-type and Tumour sub-group in the Curative or Non-curative setting. This content will be updated regularly and communicated to ESMO Members.

Tested Agent(s) Combined Agent(s) Control Arm Treatment Setting Tumour Type Tumour Sub-type Tumour Sub-group Tumour Stage Score Ref. Score card
FOLFIRINOX Gemcitabine 1st line advanced or metastatic. Good performance status Gastrointestinal Cancers Pancreatic cancer Metastatic
5
Nivolumab Chemotherapy Platinum-refractory metastatic H+N squamous cell cancer stratified for PD-L1 Head and neck cancer Squamous cell Metastatic
5
Pembrolizumab Docetaxel 2nd line after platinum-based therapy OR TKI (for EGFR/ALK Mutated) advanced NSCLC>1% tumour cell PD-L1 expression (all) Pembro 2mg/kg Thoracic Malignancies Non-small-cell Lung Cancer Metastatic
5
Pembrolizumab Docetaxel 2nd line after platinum-based therapy OR TKI (for EGFR/ALK Mutated) advanced NSCLC>1% tumour cell PD-L1 expression (all) Pembro 10mg/kg Thoracic Malignancies Non-small-cell Lung Cancer Metastatic
5
Pembrolizumab Docetaxel 2nd line after platinum-based therapy OR TKI (for EGFR/ALK Mutated) advanced NSCLC >50% tumour cell PD-L1 expression Pembro 2mg/kg Thoracic Malignancies Non-small-cell Lung Cancer Metastatic
5
Pembrolizumab Docetaxel 2nd line after platinum-based therapy OR TKI (for EGFR/ALK Mutated) advanced NSCLC>50% tumour cell PD-L1 expression Pembro 10mg/kg Thoracic Malignancies Non-small-cell Lung Cancer Metastatic
5
Nivolumab Docetaxel 2nd line after platinum-based therapy advanced squamous-cell NSCLC Thoracic Malignancies Non-small-cell Lung Cancer Squamous cell Metastatic
5
Nivolumab Docetaxel 2nd line after platinum-based therapy advanced non-squamous-cell NSCLC stratified for PD-L1 Thoracic Malignancies Non-small-cell Lung Cancer Non-squamous cell Metastatic
5
Radium-223 Best standard of care Best standard of care + placebo Late line and bone pain, castration-refractory, late line and bone pain Genitourinary Cancers Prostate cancer Metastatic
5
Nivolumab Everolimus 2nd line RCC clear cell after TKI Genitourinary Cancers Renal cell cancer Metastatic
5

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