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ESMO-Magnitude of Clinical Benefit Scale

ESMO MCBS  1000x150

The searchable portal provides a centralised location of cancer medicines that have been scored and published by ESMO.

The ESMO-MCBS Score Card

The ESMO-MCBS Score Card allows you to filter either by Agent, Tumour or Score giving priority to different criteria such as Agent and Tumour Type and Tumour sub-type and Tumour sub-group in the Curative or Non-curative setting. This content will be updated regularly and communicated to ESMO Members.

Tested Agent(s) Combined Agent(s) Control Arm Treatment Setting Tumour Type Tumour Sub-type Tumour Sub-group Tumour Stage Score Ref. Score card
Trastuzumab Chemotherapy Adjuvant or neo-adjuvant HER2 positive tumours Breast Cancer Breast Cancer HER2+ Early
A
Epirubicin, 5FU, Cisplatin Surgery Peri-operative Gastrointestinal Cancers Oesophageal or Gastric Cancer Early
A
5FU, Cisplatin Surgery Peri-operative Gastrointestinal Cancers Oesophageal or Gastric Cancer Early
A
Ipilimumab Placebo Adjuvant stage III melanoma Skin Cancers Melanoma Early
A
Ipilimumab Dacarbazine Dacarbazine + placebo 1st line metastatic Skin Cancers Melanoma Metastatic
4
Dinutuximab Cis retinoic acid+GMCSF+IL2 Cis retinoic acid <32 years old with high-risk neuroblastoma after remission and stem cell transplatation Central Nervous System Malignancies Neuro-oncology cancer Neuroblastoma Early
A
FLOT (docetaxel, oxaliplatin, fluorouracil and leucovorin) Fluorouracil or capecitabine plus cisplatin and epirubicin Resectable gastric or gastro-oesophageal junction adenocarcinoma with clinical stage cT2 or higher, nodal positive (cN+) disease or both Gastrointestinal Cancers Gastric and gastro-oesophageal junction cancers Early
A
Gemcitabine Capecitabine Gemcitabine Resected pancreatic ductal adenocarcinoma Gastrointestinal Cancers Pancreatic cancer Early
A
mFOLFIRINOX Gemcitabine Resected pancreatic ductal adenocarcinoma Gastrointestinal Cancers Pancreatic cancer Early
A
Neratinib Placebo After trastuzumab based adjuvant therapy in early HER2+ Breast Cancer Breast Cancer HER2+ Early
A

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