29 November 2020
8 January 2021
1 April 2021 onwards
Lab-based PhD fellowship (4 years) for Clinicians
Pancreatic Ductal Adenocarcinoma (PDA) is a dismal disease with late detection, limited treatment option and poor outcome. A hallmark of PDA is an extensive desmoplastic reaction where stromal cells, such as immune cells and cancer-associated fibroblasts, provide a pro-tumorigenic environment. While much effort is aimed at targeting the desmoplasia, little is known of the compositional variation across patients and which markers can be optimally used for patient stratification. In this project, we aim to implement workflows to analyse stromal cell populations across patients and with the aim of developing a digital (stromal) pathology atlas for patient stratification. The fellow will be based in a highly collaborative environment across CRUK Manchester Institute, MCRC, Christie Foundation Trust and MFT Foundation Trust and will also collaborate across Precision-Panc.
Lead supervisor: Dr Claus Jorgensen
Co-supervisor(s): Professor Ged Brady and Professor Juan Valle.
Training Experience Required
Candidates for CRTFS must be post-registration clinicians and ideally, have a specialist post in a related subject. It is generally expected that CRTFs would return to a training programme in the UK upon completion of their research degree.