Methodology

These Clinical Practice Guidelines were developed in accordance with the ESMO standard operating procedures for Clinical Practice Guidelines development. The relevant literature has been selected by the expert authors. A summary of recommendations is provided in Table 4. A MCBS table with ESMO-MCBS scores is included in Table 5. ESMO-MCBS v1.1 was used to calculate scores for new therapies/indications approved by the EMA since 1 January 2016 [322]. Levels of evidence and grades of recommendation have been applied using the systemshown in Table 6; some statements may be accompanied by a grade of recommendation alone. Statements without grading were considered justified standard clinical practice by the experts and the ESMO faculty.

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