ESMO Magnitude of Clinical Benefit Scale: Scale Evaluation Forms v1.0 & v1.1

The ESMO Magnitude of Clinical Benefit Scale uses a rational, structured and consistent approach to derive a relative ranking of the magnitude of clinically meaningful benefit that can be expected from anti-cancer treatments.

The ESMO-MCBS v1.0 was launched in May 2015 and in September 2017 an updated version ESMO-MCBS v1.1 was launched.  The forms and instructions for both versions can be found by selecting below: 

Scale Evaluation Forms 1.0   Scale Evaluation Forms 1.1

The highest grade of the ESMO-MCBS is A in the curative setting and this is restricted to new curative treatments with a grade B also to be considered to trigger rapid reimbursement.

For non-curative indications 5 is the highest possible grade with 4 also to be considered to trigger rapid consideration for reimbursement.

MCBS Score Pyramid