Clinical research PhD fellowship

Publication date: 7 November 2019

Institution

The University of Manchester
Cancer Research UK
Manchester Institute
Manchester
UK

Job

Job Title

Clinical research PhD Fellowship: "Creating and annotating a digital pathology atlas for primary and metastatic PDA"

Project Summary

Creating and annotating a digital pathology atlas for primary and metastatic PDA.
Pancreatic Ductal Adenocarcinoma (PDA) is a dismal disease with late detection, limited treatment option and poor outcome. A hallmark of PDA is an extensive desmoplastic reaction where stromal cells, such as immune cells and cancer-associated fibroblasts, provide a pro-tumorigenic environment. While much effort is aimed at targeting the desmoplasia, little is known of the compositional variation across patients and which markers can be optimally used for patient stratification. In this project, we aim to implement workflows for single cell protein analysis of stromal cell populations across patients and will use this to develop a digital (stromal) pathology atlas for patient stratification. Specifically, the fellow will use Cytometry by Time of Flight (CyTOF) to annotate stromal cell populations and integrate this with known patient information. The fellow will be based in a highly collaborative environment across CRUK Manchester Institute, MCRC, Christie Foundation Trust and MFT Foundation Trust and will also collaborate across Precision-Panc.

Entry Requirements

Candidates must be post-registration clinicians and ideally have a specialist post in a related subject, for example, obstetrics and gynaecology, oncology, or primary care.

Applicants must have been resident and worked within the EEA (European Economic Area) for at least three years prior to application.

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How to apply

Contact Person: Claus Jorgensen
Email: Claus.Jorgensen@cruk.manchester.ac.uk

Application deadline

Deadline for application is 1 December 2019

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