ESMO E-Learning: Clinical Cases in GIST: Adherence to the ESMO Clinical Practice Guidelines
- To understand the importance of KIT and PDGRFA mutational analysis in GIST patients: diagnostic, predictive and prognostic value.
- To understand the importance and the usefulness of radiological investigations, especially when assessing the response of tumor: changes in size and density, limitation of RECIST criteria.
- To understand the role of biological therapy in GIST patients in the adjuvant and metastatic settings.
This presentation has been developed with the purpose of discussing clinical perspectives and enhancing practice implementation of recently revised ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of gastrointestinal stromal tumours (GIST). The module consists of two particular patient cases: the first case describes diagnosis, clinical scenario and adjuvant treatment in a patient with localised GIST and the second deals with the clinical course and treatment strategies in a patient with metastatic disease.
GIST is one of the many histologic subsets of the soft tissue sarcomas and the most common mesenchymal neoplasm of the gastrointestinal tract. Clinical trials data in the systemic management of GIST have been sparse over the past few decades, owing to the resistance to conventional cytotoxic chemotherapeutics and radiation interventions. However, recent breakthroughs in the understanding of this malignancy's pathogenesis and the advent of small-molecule targeted signal transduction inhibitors and anti-angiogenesis agents have led to the approval of innovative therapies that have changed the natural history of the disease.
This E-Learning module utilises patient case-based discussions to enhance the use of evidence-based concepts in routine clinical practice. By providing an expert perspective on the disease, this activity will assist oncology practitioners in the application of optimal clinical management strategies. The module presents facts included in the latest revision of the ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up of GIST by ESMO/CONTICANET/EUROBONET Consensus Panel of Experts.
Aiming to enhance experience with the ESMO Clinical Practice Guidelines material, we strongly recommend oncology professionals to refer to the full version of the guideline text available in the May Supplement of the Annals of Oncology, as well as the Clinical Practice Guidelines section of the ESMO website.
This E-Learning module was published in 2011 and expired in 2013.
The author has reported no conflicts of interest.