Patented computerised system promises to accelerate cancer trials
The system matches registered patients' own molecular profiles, warehoused in a database of patient-donated biological tissue or tumour samples, to the molecular design of drugs
- Date : 21 Jun 2012
- Topic : Pathology/Molecular biology
A new patent has been issued to Moffitt Cancer Centre in Tampa, USA for a computerised system that efficiently selects the right patient for the right clinical trial. The system matches registered patients' own molecular profiles—warehoused in a database of thousands of patient-donated biological tissue or tumour samples—to the molecular design of drugs aimed at targeting their disease at the molecular level, and does it quickly. The system promises to accelerate clinical trials and help shorten the time that it takes to get critically needed new drugs into the market.
Selection of patients to clinical trials based on matching an individual's/drug's molecular profile
The complex development process for getting new drugs to market to fight cancer and other serious diseases requires, on average, 15 years. The three-phase clinical trials process — estimated to take up to half of those 15 years — is often the bottleneck in getting innovative drugs to the patients who need them.
Clinical trials, increasingly becoming more expensive, are also multifaceted. While patients may qualify for a clinical trial based on their age or stage of disease, they may not be, over the long term of the trial, the best candidates on which to test a drug. Adverse events, changes in patients' health status, and the potential for a drug not being effective for them slow the process. Indeed, although patients may have met the trial protocol's criteria, the drug may not be right for them because their molecular profile is not a good match for the chemical and molecular properties of the drug.
With the development of new and better ways to examine and understand a tumour's molecular profile, matching the right patient to the right clinical trial becomes increasingly important. However, handling the massive data evaluation necessary to accomplish this has been a stumbling block. The newly patented computer system, Patent Number US 8,095,389 B2, or "Computer Systems and Methods for Selecting Patients for Clinical Trials," is designed to surmount that problem.
The newly patented computer system is designed to:
- Select patients for clinical trials by matching an individual's/drug's molecular profile
- Match patients to clinical trials by a patient's disease/diagnosis
- Match patients to clinical trials by their symptoms
- Match patients to clinical trials by their demographic information and family history
- Track a clinical trial participant's disease progression compared to drug efficacy.
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