Large analytic review finds a risk for mild cognitive deficits after standard dose chemotherapy
“Chemo brain” in breast cancer survivors
- Date : 06 Sep 2012
- Topic : Breast cancer
A large meta-analysis conducted by researchers at Moffitt Cancer Centre has concluded that breast cancer patients treated with chemotherapy are at risk for mild cognitive deficits after treatment. The meta-analysis of previously published studies found that study participants on average had mild impairments in verbal abilities (such as difficulty choosing words) and visuospatial abilities (such as getting lost more easily). The study noted that cognitive functioning varies across survivors, with some reporting no impairments and others reporting more severe or pervasive deficits.
Cognitive functioning in patients who had received standard dose chemotherapy
The objective of this analysis was to clarify existing research on cognitive functioning in patients who had received standard dose chemotherapy for breast cancer at least six months previously. According to a study lead author Heather Jim, PhD, an assistant member at Moffitt whose research focuses on the psychosocial and behavioural aspects of cancer survivorship, earlier studies had reported conflicting evidence on the severity of cognitive deficits, especially over the long term.
Although this is an active area of research, an overall analysis of the studies had not been performed since 2006, explained the researchers. The analysis indicated that patients previously treated with chemotherapy performed significantly worse on tests of verbal ability than individuals without cancer. The study co-author Paul Jacobsen, Moffitt senior member and associate centre director of Population Sciences, noted that patients treated with chemotherapy performed also significantly worse on tests of visuospatial ability than patients who had not had chemotherapy.
Breast cancer patients treated with chemotherapy who have subsequent cognitive deficits should be referred to a neuropsychologist for evaluation and management of the deficits according to the authors. Management usually involves developing an awareness of the situations in which their cognitive difficulties are likely to arise so that they can come up with strategies to compensate. Research shows that such strategies can make a big difference in daily life when cognitive difficulties do arise.
The study was published in a recent issue of the Journal of Clinical Oncology. The research was supported in part by the USA National Cancer Institute, part of the National Institutes of Health, through grant number K07 CA138499.
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